CADM1 Antibody
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Product Specs
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze / thaw cycles.
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your orders. Delivery time may vary depending on the purchase method or location. Please consult your local distributors for specific delivery times.
Synonyms
BL2 antibody; Cadm1 antibody; CADM1_HUMAN antibody; Cell adhesion molecule 1 antibody; DKFZp686F1789 antibody; IgSF4 antibody; IGSF4A antibody; Immunoglobulin superfamily member 4 antibody; MGC149785 antibody; MGC51880 antibody; NECL-2 antibody; NECL2 antibody; Nectin like 2 antibody; Nectin-like protein 2 antibody; RA175 antibody; SgIGSF antibody; Spermatogenic immunoglobulin superfamily antibody; ST17 antibody; sTSLC 1 antibody; Synaptic cell adhesion molecule antibody; SynCAM antibody; SynCAM1 antibody; TSLC-1 antibody; TSLC1 antibody; Tumor suppressor in lung cancer 1 antibody
Target Names
Uniprot No.
Target Background
Function
CADM1 (Cell Adhesion Molecule 1) is a transmembrane protein that mediates homophilic cell-cell adhesion in a calcium-independent manner. It also participates in heterophilic cell-cell adhesion with CADM3 and NECTIN3, again independent of calcium. Interaction with CRTAM (Cellular Receptor for the Transmembrane Antigen) enhances natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro, as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. In mast cells, CADM1 may mediate attachment to and promote communication with nerves. Notably, CADM1, alongside MITF (Microphthalmia-associated Transcription Factor), is essential for the development and survival of mast cells in vivo. By interacting with CRTAM and thus promoting adhesion between CD8+ T-cells and CD8+ dendritic cells, CADM1 regulates the retention of activated CD8+ T-cells within the draining lymph node. It is crucial for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. The interaction with CRTAM facilitates adhesion to gut-associated CD103+ dendritic cells, which may contribute to the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells. Acting as a synaptic cell adhesion molecule, CADM1 plays a role in the formation of dendritic spines and synapse assembly. It may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. CADM1 likely plays diverse roles in spermatogenesis, including the adhesion of spermatocytes and spermatids to Sertoli cells and their normal differentiation into mature spermatozoa. CADM1 functions as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. It may contribute to the less invasive phenotypes of lepidic growth tumor cells.
Gene References Into Functions
- miRNA-873 promotes Hepatocellular Carcinoma progression by targeting TSLC1. PMID: 29734164
- High CADM1 expression is associated with KSHV infection. PMID: 29698475
- The immunohistochemical expression of CADM1 has the potential to serve as an auxiliary tool in the differential diagnosis between nevi and melanomas. PMID: 28843749
- These findings suggest that CADM1 expression is a novel prognostic factor for peripheral T cell lymphoma, not otherwise specified. PMID: 28940014
- miR-21 enhances chemo-resistance in tongue cancer cells via direct targeting of CADM1, and an inverse correlation between miR-21 and CADM1 expression is observed in vivo. MiR-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer. PMID: 27055844
- We conclude that CADM1 was not associated with cell-cell interaction between lymphoma cells and macrophages, although CADM1 may be a valuable marker of ATLL for diagnostic procedures. PMID: 28420814
- miR-21 overexpression promotes cardiac fibrosis via the STAT3 signaling pathway by decreasing CADM1 expression, indicating miR-21 as an important signaling molecule for cardiac fibrotic remodeling and atrial fibrillation. PMID: 28335740
- Pathway analysis of genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (cg16962115, FDR = 1.24E-04), CADM1 (cg21933078, FDR = 1.22E-02) and NFATC1 (cg06784563, FDR = 1.46E-02). PMID: 28637314
- CADM1 mRNA expression was highly upregulated in normal tissues compared to esophageal squamous cell carcinoma tissues, indicating that the loss of CADM1 expression influenced the pathogenesis, invasion, and metastasis of ESCC. PMID: 28510248
- Eight and five of the nine samples were negative for cell adhesion molecule 1 and Osterix, respectively. Other markers showed no statistical significance (CD151, ALP). Osteoblastic differentiation can occur in carcinoma cells, and cell adhesion molecule 1 could be a useful marker for identifying this phenomenon in carcinoma tissues. PMID: 28651491
- Our results suggest that, as in the CNS, CADM1 interactions drive exocytic site assembly and promote actin network formation. These findings support the broader hypothesis that the effects of cell-cell contact on beta-cell maturation and function are mediated by the same extracellular protein interactions that drive the formation of the presynaptic exocytic machinery. These interactions may be therapeutic targets for re... PMID: 27072493
- High expression of CADM1 on most HTLV-1-infected cells in the face of enhanced cytotoxic T lymphocyte counterselection implies that CADM1 confers a strong benefit on the virus. PMID: 27105228
- Decreased expression of TSLC1 is associated with differentiation in ovarian epithelial cancer. TSLC1 might be used as a molecular marker of severity in early stage ovarian cancer, and to help differentiate benign and malignant ovarian tumors. PMID: 27146728
- Suppression of tumorigenesis by CADM1 may be mediated by the Rb-E2F1 pathway. PMID: 27298105
- CADM1 prevents squamous cell carcinoma progression by reducing STAT3 activity. PMID: 27035095
- Decreased expression of TSLC1 is correlated with the malignancy of non-muscle invasive bladder cancer tissues, and low TSLC1 expression may serve as a predictor for bladder cancer recurrence and progression. PMID: 26894268
- CADM1 deletion is associated with neuroblastoma and ganglioneuroma. PMID: 26463893
- Hypermethylation of the CADM1 gene may be highly associated with the development of cervical cancer. PMID: 26552048
- Our study showed that miR-126, by down-regulation of CADM1, enhances migration and invasion in gastric cancer cells. PMID: 26464628
- This study revealed that Merkel cell polyomavirus-negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL than Merkel cell polyomavirus-positive Merkel cell carcinomas. PMID: 26772392
- CADM1/MAL methylation increases with the severity of cervical intraepithelial neoplasia. PMID: 26219541
- SynCAM1 delineates the postsynaptic perimeter of the synaptic cleft as determined by immunoelectron microscopy. PMID: 26687224
- Increased ectodomain shedding of cell adhesion molecule 1 from pancreatic islets in type 2 diabetic pancreata. PMID: 24964098
- In a population-based association study, we confirm a role for CADM1 variants in increasing the risk of VT by interaction with protein C pathway abnormalities. PMID: 25306186
- The significant association of IGSF4 with HPV-positive head and neck squamous cell carcinoma suggests that HPV-positive tumors are to a greater extent driven by promoter hypermethylation in this tumor suppressor gene. PMID: 25569158
- HPV-positive oropharyngeal squamous cell carcinoma is associated with TIMP3 and CADM1 promoter hypermethylation. PMID: 25065733
- CADM1/TSLC1 is an antiinvasive gene, the overexpression of which inhibits the invasion of A375 cells. PMID: 25215547
- Cytology and bi-marker CADM1/MAL-methylation analysis perform complementary for CIN2+/CIN3+ detection when used as a triage tool on cervical scrapes of HPV positive women. PMID: 25667975
- TSLC1-AS1 was a tumor suppressor of glioma and a mediator of TSLC1 expression. PMID: 25031725
- The study showed that CADM1 is a direct target of miR-1246 leading to its down regulation in hepatocellular carcinoma cells. PMID: 25159494
- DNA methylation analysis of CADM1, MAL and miR124-2 in cervical scrapes consistently detects cervical cancer. PMID: 25281766
- Loss of CADM1 expression is an independent prognostic factor especially associated with the development of brain metastases in breast cancer patients. PMID: 24833255
- We showed that the CADM1 versus CD7 plot is capable of discriminating clonally expanding HTLV-I-infected cells in indolent and acute-type T-cell leukemia-lymphomas and in asymptomatic carriers. PMID: 24727323
- MPP3 and Dlg, membrane-associated guanylate kinase homologs (MAGuK) proteins, connect CADM1 with p85 of PI3K by forming a multi-protein complex at the periphery of cells. PMID: 24503895
- Data suggest that cell adhesion molecule 1 (CADM1) is a key adhesion receptor, which regulates mast cells (MCs) net adhesion. PMID: 24465823
- TGF-beta upregulates miR-182 expression to promote gallbladder cancer metastasis by targeting CADM1. PMID: 24445397
- CADM1 ectodomain shedding appeared to cause alveolar cell apoptosis in emphysematous lungs by producing alphaCTF that accumulated in mitochondria. PMID: 24092566
- The paper shows that CADM1 regulates mast cell net adhesion, both directly through CADM1-dependent adhesion, and indirectly through the regulation of other adhesion receptors. The latter is likely to occur via docking of KIT and polymerization of cortical F-actin. CADM1 is involved in docking of KIT to the cell surface and phosphotyrisine signaling, and polymerization of cortical F-actin. PMID: 24465823
- SynCAM, a novel putative tumor suppressor, suppresses growth and invasiveness of glioblastoma. PMID: 23907434
- Infection of NCI-H460, A549, and H1299 lung cancer cells with Ad.sp-E1A(Delta24)-TSLC1 induced apoptosis. PMID: 23503473
- Data suggest that tumor suppressor in lung cancer 1 (TSLC1) as tumor suppressor may play prominent roles in development and progression of cutaneous squamous cell carcinoma (CSCC) via regulation of different biological processes. PMID: 23812766
- The cell adhesion molecule Necl-2 competitively binds the immune receptor CRTAM. PMID: 23871486
Database Links
Protein Families
Nectin family
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse.
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