CADM2 Antibody
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Description
Applications in Research
CADM2 antibodies are widely used in:
Oncogenic Suppression
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Glioma: CADM2 overexpression inhibits proliferation (57.6% reduction in U87 cells) and metastasis by downregulating β-catenin and upregulating E-cadherin .
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Colorectal Cancer: Low CADM2 correlates with advanced tumor stage and poor survival (HR = 2.1, p < 0.001) .
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Lung Cancer: Silencing CADM2 enhances EMT, increasing brain metastasis risk (OR = 3.2) .
Mechanistic Insights
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Cell Cycle Regulation: Reduces cyclin D1 and CDK4/2 expression, arresting G1/S transition .
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EMT Modulation: Suppresses vimentin and Slug while enhancing E-cadherin in HCC and NSCLC .
Clinical Implications
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Biomarker Potential: CADM2 expression predicts survival in glioma (median OS: 22 vs. 14 months, high vs. low) and CRC (AUC = 0.84) .
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Therapeutic Target: Restoring CADM2 inhibits FAK/AKT signaling, reducing HCC metastasis .
Limitations and Future Directions
Product Specs
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Lead Time
Typically, we can ship your orders within 1-3 business days after receiving them. Delivery times may vary depending on the purchase method or location. Please consult your local distributor for specific delivery times.
Synonyms
CADM2 antibody; CADM2_HUMAN antibody; Cell adhesion molecule 2 antibody; IgSF4D antibody; Immunoglobulin superfamily member 4D antibody; NECL 2 antibody; Necl 3 antibody; NECL-3 antibody; NECL2 antibody; Necl3 antibody; Nectin like protein 3 antibody; Nectin-like protein 3 antibody; synCAM 2 antibody; synCAM2 antibody
Target Names
CADM2
Uniprot No.
Target Background
Function
CADM2, also known as Cell Adhesion Molecule 2, is an adhesion molecule that participates in both homo- and heterophilic interactions with other members of the nectin-like family. These interactions lead to cell aggregation, playing a crucial role in synapse organization by providing regulated trans-synaptic adhesion. Notably, CADM2 exhibits a preferential binding affinity for oligodendrocytes.
Gene References Into Functions
- Ectopic expression of CADM2 has been shown to counteract the promoting effect of miR-146a on cell proliferation, migration, invasion, and the epithelial-mesenchymal transition process. PMID: 30184528
- Studies have indicated that CADM2 single-nucleotide polymorphisms (SNPs) are associated with lifetime cannabis use, although the association did not reach genome-wide significance. [Meta-Analysis] PMID: 27023175
- A significant association was observed for the SNP rs17518584 in the joint discovery and replication meta-analysis, located in an intron of the CADM2 gene, for performance on the LDST/DSST cognitive test. PMID: 25869804
- In the absence of SynCAMs, selective axon-axon interactions are disrupted, leading to aberrant pathfinding of sensory axons. PMID: 25335893
- Cox regression analysis has identified CADM2 expression level, tumor size, tumor number, vascular invasion, and HBsAg as independent risk factors for hepatocellular carcinoma (HCC) recurrence. PMID: 24240726
- Research findings suggest that CADM2 functions as a novel tumor suppressor and may hold potential as a therapeutic target for human renal cell carcinoma. PMID: 23643812
- Evidence suggests that CADM2 is one of the pathogenic factors contributing to psoriasis. PMID: 21864505
- The expression of CADM2 is regulated in part by promoter methylation, implicating it as a previously unrecognized tumor suppressor gene in a proportion of human prostate cancers. PMID: 21062931
- Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19861958
Database Links
Protein Families
Nectin family
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons.
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