CAMKK2 Antibody

1. Silencing of TRPC5 and inhibition of autophagy reverses adriamycin drug resistance in breast carcinoma via the CaMKKbeta/AMPKalpha/mTOR pathway. PMID: 28600513
2. Studies have shown that SSd induces autophagy through the CaMKKbeta-AMPK-mTOR signaling pathway in Autosomal dominant polycystic kidney disease (ADPKD) cells, suggesting that SSd could be a potential therapy for ADPKD, and that SERCA might be a new target for ADPKD treatment. PMID: 29675630
3. Three single nucleotide polymorphisms (SNPs) within P2X4R and two SNPs within CAMKK2 were found to influence TNFalpha concentrations in peripheral blood mononuclear cells. However, these SNPs were not associated with the risk for HIV-associated sensory neuropathy in South Africans. PMID: 29428485
4. Serum CAMKK2 levels were downregulated in female schizophrenic patients compared to female healthy individuals. PMID: 29992499
5. This study provides insights into functionally disruptive, rare-variant mutations in human CaMKK2, which may potentially influence the risk and burden of disease associated with aberrant CaMKK2 activity in human populations carrying these variants. PMID: 28230171
6. 14-3-3gamma protein directly interacts with the kinase domain of CaMKK2 and the region containing the inhibitory phosphorylation site Thr(145) within the N-terminal extension. CaMKK isoforms differ in their 14-3-3-mediated regulations, and the interaction between 14-3-3 protein and the N-terminal 14-3-3-binding motif of CaMKK2 might be stabilized by small-molecule compounds. PMID: 29649512
7. CAMKK2 exhibited the strongest associations with HIV-associated sensory neuropathy (HIV-SN), with two SNPs and six haplotypes predicting SN status in black Southern Africans. PMID: 26785644
8. A study utilized three cognitive tasks and fMRI to provide convergent evidence of a link between the rs1063843 SNP of CAMKK2 and the function of the dorsolateral prefrontal cortex. Furthermore, this polymorphism was associated with the function of the striatum during a working memory task. PMID: 27004598
9. Data suggest that CAMKK2 is highly expressed in high-grade ovarian cancer and ovarian cancer cell lines; CAMKK2 directly activates Akt1 by phosphorylation at Thr-308 in a Ca2+/calmodulin-dependent manner; CAMKK2 knockdown or inhibition decreases Akt1 phosphorylation at Thr-308 and Ser-473. (CAMKK2 = calcium/calmodulin dependent protein kinase kinase 2; AKT1 = AKT serine/threonine kinase 1) PMID: 28634229
10. Single nucleotide polymorphism in the CAMKK2 gene is associated with pulmonary non-tuberculous mycobacterial disease. PMID: 28233049
11. This study demonstrated that the expression level of CAMKK2 could be regulated by promoter methylation. CAMKK2 serves as a prognostic marker in gliomas and could be a potential therapeutic target in gliomas. PMID: 27012733
12. For the first time, it was shown that rs1063843, a single nucleotide polymorphism located in the CAMKK2 gene, is highly associated with bipolar disorder. PMID: 26354101
13. Site-directed mutagenesis analysis revealed that Leu(358) in CaMKKbeta/Ile(322) in CaMKKalpha confer, at least in part, a distinct recognition of AMPK but not of CaMKIalpha. PMID: 27151216
14. Clopidogrel diminishes TNFalpha-stimulated VCAM-1 expression at least in part via HO-1 induction and the CaMKKbeta/AMPK/Nrf2 pathway in endothelial cells. PMID: 26824050
15. CaMKK2 (and Nup62) are required for optimal androgen receptor transcriptional activity in castrate resistant prostate cancer cells. PMID: 26552607
16. Silencing of CAMKK2 using siRNA significantly reduced cell proliferation, colony formation, and invasion of gastric cancer cells. PMID: 25756516
17. CaMKKbeta-AMPKalpha2 signaling contributes to mitotic Golgi fragmentation and the G2/M transition in mammalian cells. PMID: 25590814
18. CAMKK2 protein is highly upregulated in hepatocellular carcinoma. PMID: 25847065
19. CaMKK2 plays a pivotal role in the calcium signaling cascade regulating adrenal aldosterone production. PMID: 25679868
20. PCa patients with miR-224-low/CAMKK2-high expression more frequently had shorter overall survival. PMID: 25394900
21. Evidence supports that CAMKK2 is a novel schizophrenia susceptibility gene. PMID: 23958956
22. CaMKIIalpha phosphorylation was enhanced by S-Allyl cysteine treatment in a concentration- and time-dependent manner, which paralleled AMPK activation. PMID: 23465592
23. Pulsatile shear stress mimicking atheroprotective flow increases the level of sirtuin (SIRT)1 in cultured endothelial cells by enhancing its stability, an effect abolished by inhibition or knockdown of CaMKKbeta. PMID: 23754392
24. CaMKKbeta is involved in AMP-activated protein kinase activation by baicalin in LKB1 deficient cell lines. PMID: 23110126
25. Amino acid starvation regulates autophagy in part through an increase in cellular Ca(2+) that activates a CaMKK-beta-AMPK pathway and inhibits mTORC1, which results in ULK1 stimulation. PMID: 23027865
26. Calcium/calmodulin-dependent protein kinase kinase 2 has roles in signaling and pathophysiology [review]. PMID: 22778263
27. Data show that in PCa progression, CaMKK2 and the AR are in a feedback loop in which CaMKK2 is induced by the AR to maintain AR activity, AR-dependent cell cycle control, and continued cell proliferation. PMID: 22654108
28. Data show that protein kinase A (PKA) regulates the alternative splicing of Ca(2)/calmodulin-dependent protein kinase kinase 2 (CaMKK2) to produce variants that differentially modulate neuronal differentiation. PMID: 21957496
29. Phosphorylation of CaMKKbeta regulates its half-life. PMID: 21669867
30. Our results demonstrate that CaMKKbeta and AMP-activated protein kinase form a unique signaling complex. PMID: 21807092
31. Findings reveal that hypoxia can trigger AMPK activation in the apparent absence of increased [AMP] through ROS-dependent CRAC channel activation, leading to increases in cytosolic calcium that activate the AMPK upstream kinase CaMKKbeta. PMID: 21670147
32. These results suggest that CaMKK is an important factor for human cytomegalovirus replication and human cytomegalovirus-mediated glycolytic activation. PMID: 21084482
33. CaMKK is involved in both S1P receptor- and SR-BI-mediated phosphorylation of AMPK, Akt, and eNOS. PMID: 20018878
34. ERK activation and cell growth require CaM kinases in MCF-7 breast cancer cells. PMID: 19763792
35. Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex. There is a synergistic effect of Ca2+ and AMP. PMID: 19958286
36. There is significant basal activity and phosphorylation of AMPK in LKB1-deficient cells that can be stimulated by Ca2+ ionophores, and studies using the CaMKK inhibitor STO-609 and isoform-specific siRNAs show that CaMKKbeta is required for this effect. PMID: 16054095
37. Overexpression of CaMKKbeta in mammalian cells increases AMPK activity, whereas pharmacological inhibition of CaMKK, or downregulation of CaMKKbeta using RNA interference, almost completely abolishes AMPK activation. PMID: 16054096
38. Endothelial cells possess two pathways to activate AMPK, one Ca2+/CaMKKbeta dependent and one AMP/LKB1 dependent. PMID: 16880506
39. A prominent association was found between the severity of panic- and agoraphobia symptoms and an exonic SNP (rs3817190) in the CaMKKb gene, and a trend for association with an exonic SNP in P2RX7 (rs1718119) with severity scores in the panic- and agoraphobia scale. PMID: 17197037
40. Modulating basal AMPK and CAMKKB activity in the hypothalamus is essential for maintaining tight regulation of pathways contributing to food intake. PMID: 18436530
41. Growth of cervical cancer cells was inhibited through activation of CAMKK2 and LBK1. PMID: 19407487
42. Data show that the prototypical CaM target sequence skMLCK, a fragment from skeletal muscle myosin light chain kinase, binds to CaM in a highly cooperative way, while only a lower degree of interdomain binding cooperativity emerges for CaMKK. PMID: 19667195

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HGNC: 1470

OMIM: 615002

KEGG: hsa:10645

STRING: 9606.ENSP00000312741

UniGene: Hs.297343