CBR3 Antibody

• The CBR3 730G>A polymorphism has been significantly associated with recurrence-free survival in patients who underwent complete transurethral resection followed by intravesical chemotherapy with pirarubicin. PMID: 30125887
• Studies have not found a significant correlation between cardiotoxicity and single nucleotide polymorphisms (SNPs) within the CBR pathway. Further investigation into CBR SNPs in a larger adult population is required. PMID: 26563179
• Research suggests an association of SNPs in ABCB1 and CBR3 with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines. PMID: 26799497
• Variants of CBR3 and GSTP1 enzymes may be associated with alterations in short-term functional cardiac parameters. PMID: 23182048
• Genetic polymorphism in the CBR3 gene has been linked to an increased risk of type 2 diabetes and insulin resistance in Chinese populations. This association is likely mediated through modulation of adipogenesis. PMID: 22527884
• Polymorphisms in CBR3 contribute to an elevated risk of cardiomyopathy associated with anthracycline treatment of childhood cancer. PMID: 22124095
• CBR3 is a novel target gene of inflammatory stimuli. Further research is needed to elucidate its detailed role in inflammation. PMID: 22425771
• Computational analysis has identified a conserved antioxidant response element (ARE) in the distal carbonyl reductase 3 (CBR3) promoter region. PMID: 22001310
• The CBR3 distal promoter contains an activating cis-regulatory element that responds to Trichostatin A (TSA) treatment, as demonstrated by promoter reporter assays in HEK 293 cells. PMID: 20494980
• CBR3 is regulated via NRF2-dependent signaling pathways, highlighting its crucial role in the cellular response to oxidative stress. PMID: 20806931
• Studies have analyzed the structural basis for substrate specificity in human monomeric carbonyl reductases CBR3. PMID: 19841672
• The common carbonyl reductase 3 (CBR3) valine244methionine polymorphism encodes for CBR3 isoforms with distinct enzymatic properties, as revealed in DNA variation panels from 10 ethnic groups. PMID: 15537833
• There is a trend suggesting an association between the CBR3 V244M polymorphism and the risk of heart failure. PMID: 18457324
• Polymorphisms in CBR3 may account for interindividual and interethnic variability in doxorubicin pharmacokinetics and pharmacodynamics. PMID: 18551042
• CBR3 polymorphisms have no significant influence on the pharmacokinetics of doxorubicin in Asian breast cancer patients. PMID: 19016765
• Researchers have identified the promoter of human CBR3. Liver samples from Black donors showed higher relative CBR3 mRNA levels compared to samples from White donors. PMID: 19590938
• Carbonyl reductase plays a significant role in modifying the metastatic behavior of malignant tumors. PMID: 10728668
• Decreased Carbonyl Reductase expression in epithelial ovarian cancer is associated with regional lymph node metastasis and poor survival. PMID: 11592776

HGNC: 1549

OMIM: 603608

KEGG: hsa:874

STRING: 9606.ENSP00000290354

UniGene: Hs.154510