CBX1 Antibody

• The prolyl residue within the PXXVXL motif appears to have a distinct role compared to Pro in the known HP1beta CSD-PXVXL complexes. PMID: 28223359
• Research indicates that heterochromatin protein 1-beta (HP1beta) is a prototypical HP1 protein representing most fundamental chromatin binding and effects. PMID: 27090491
• Increased HP1beta expression is associated with poor prognosis in breast cancer. PMID: 25769025
• This review summarizes the current understanding of targeting and functional mechanisms of Polycomb Repressive Complexes (PRCs), highlighting recent advancements related to CBX proteins in various physiological and pathological conditions. PMID: 24793759
• Data suggest that the reduction of Heterochromatin Protein 1 isoforms HP1beta, followed by a decrease in HP1alpha, contributes to the pathogenesis of thyroid carcinomas. Their loss is a potential marker of thyroid malignancy and metastatic potential, respectively. PMID: 24840329
• Phosphorylation at Ser89 and Ser175 induces localized conformational changes in HP1beta, which do not compromise its ability to bind chromatin. PMID: 24561199
• HP1 isoforms distinctively augment Androgen Receptor (AR) signaling and cell growth in prostate cancer. Consequently, silencing HP1beta and HP1gamma may be a promising therapeutic approach for treating prostate cancer. PMID: 23536649
• The structural plasticity of HP1beta supports its capability to bind and connect a wide range of binding partners in epigenetic processes. PMID: 23585859
• HP1beta, associated with Proliferating Cell Nuclear Antigen (PCNA) in regions of DNA repair, is bound and does not exchange with the mobile pool. This suggests that HP1beta in association with PCNA may be a component of a DNA repair complex. PMID: 23337132
• The HP1beta interactome is enriched with lysine-methylated proteins. HP1beta plays a role in the DNA damage response. PMID: 23707759
• A study discovered that while HP1alpha and beta stimulate homologous recombination and single-strand annealing, HP1gamma has an inhibitory role. PMID: 23287531
• Methylation of lysine 9 in histone H3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP1beta with the nucleosome. PMID: 22815475
• HP1 beta and PCNA, a key player in DNA replication, are closely spaced components of a multiprotein complex involved in replication, both in S phase and during DNA repair. The functional complex requires the formation of an HP1 dimer. PMID: 22617335
• Abrogating Gastrin-Releasing Peptide/Gastrin-Releasing Peptide Receptor (GRP/GRPR) signaling specifically downregulates HP1(Hsbeta) expression. Inhibiting GRPR signaling or ablating HP1(Hsbeta) expression increases colon cancer cell invasiveness in vitro. PMID: 21281799
• HP1beta is involved in the proliferation of AR-expressing prostate cancer cells and progression to Castration-Resistant Prostate Cancer (CRPC) as an AR coactivator. PMID: 20308360
• Isoform-specific interaction of HP1 with human TAFII130. PMID: 11959914
• Gene regulation by human orthologs of Drosophila heterochromatin protein 1. PMID: 12054505
• Both the chromodomain and the chromoshadow domain of HP1 are required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin. PMID: 12560555
• Cells are exquisitely sensitive to the amount of HP1(Hsalpha) or HP1(Hsbeta) present, as their overexpression influences telomere stability, population doubling time, radioresistance, and tumorigenicity. PMID: 14585993
• HP1beta recruits endogenous HP1alpha to the chromatin, inducing heterochromatin formation and enhanced histone lysine methylation. PMID: 15899859
• Analysis of methylation-independent binding to histone H3 and cell cycle-dependent incorporation of HP1beta into heterochromatin. PMID: 16547356
• HP1 binding as analyzed through the crystal structure of the HP1-EMSY complex. PMID: 16615912
• Overexpression of HP1-BETA in eye imaginal discs caused abnormally patterned eyes, with reduced numbers of ommatidia. PMID: 17575412
• HP1 recruitment-release is a sequential mechanism that is precisely regulated and highly dependent on transcription. PMID: 18239689
• Findings reveal an unrecognized signaling cascade that helps to initiate the DNA damage response, altering chromatin by modifying a histone-code mediator protein, HP1, but not the code itself. PMID: 18438399
• When HP1beta was co-expressed with TIF1beta/S473A, but not TIF1beta/S473E, the colocalization of TIF1beta/S473A and HP1beta to the promoters of Cdc2 and Cdc25A was enhanced. PMID: 18590578
• A nonconventional interaction between HP1 and a tissue-specific transcription factor, MyoD, was identified. This strongly suggests that HP1 isoforms play important roles during muscle terminal differentiation in an isoform-dependent manner. PMID: 18599480

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HGNC: 1551

OMIM: 604511

KEGG: hsa:10951

STRING: 9606.ENSP00000225603

UniGene: Hs.77254