CCL19 Antibody

1. Research suggests that CCL19/CCR7 contributes to the proliferation and invasion of endometrial stromal cells (ESCs), potentially contributing to the pathogenesis of endometriosis through activation of the PI3K/Akt pathway. PMID: 28856757
2. Studies have demonstrated that CCL19, CCL21, and CCR7 play significant roles in bone destruction by promoting osteoclast migration and resorption activity, potentially linking them to the pathogenesis of rheumatoid arthritis. PMID: 28729639
3. Soluble factors derived from breast cancers have been shown to increase the migration of dendritic cells (DCs) towards CCL19. PMID: 27451948
4. The migratory index towards the CCR7 ligands, CCL19 and CCL21, was found to be higher in T-cells from donors whose recipients developed graft-versus-host disease (GvHD). PMID: 28112745
5. Research confirms that CCL19 induces the invasion and migration of breast cancer cells through the expression of epithelial-mesenchymal transition (EMT) markers. PMID: 28378417
6. Findings establish a connection between NOTCH1, DUSP22, and CCL19-driven chemotaxis within a functional network, suggesting that modulation of the homing process could play a role in the unfavorable prognosis associated with NOTCH1 mutations in chronic lymphocytic leukemia (CLL). PMID: 28017968
7. Deletion of the extended C-terminus reduces CCL21's affinity for heparin, while transferring the CCL21 C-terminus to CCL19 enhances heparin binding mainly through non-specific, electrostatic interactions. PMID: 27338641
8. CCL19 is significantly overexpressed in patients with unstable carotid atherosclerotic plaques, suggesting it may be a potential biomarker for identifying high-risk patients who may require more urgent intervention. PMID: 27498092
9. CrkL regulates CCL19 and CCR7-induced epithelial-to-mesenchymal transition via the ERK signaling pathway in epithelial ovarian carcinoma patients. PMID: 25636509
10. The solution structure of CCL19 has been reported. It contains a canonical chemokine domain. Chemical shift mapping demonstrates that the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19, and binding is competitive. PMID: 26115234
11. Research elucidates the molecular mechanisms underlying the resistin induction of CCL19 expression in endothelial cells (ECs) and the shear-stress protection against this induction. PMID: 25656506
12. The mRNA levels of CCL19/CCL21 in ankylosing spondylitis hip ligament were found to be significantly higher than in osteoarthritis ligament. PMID: 25260647
13. Serum CCL19 and CCL21 were up-regulated during Rickettsia conorii infection. PMID: 24507453
14. CCL19 promotes monocyte adhesion to human umbilical vein endothelial cells (HUVEC). CCL19 rs2227302 was associated with coronary artery disease in a Chinese Han population. PMID: 24990231
15. CCL19 exhibits antimicrobial properties with bacteriocidal activity against Escherichia coli. PMID: 12949249
16. CCL19, rather than CCL21, may contribute to the accumulation of dendritic cells and macrophages in the inflamed lungs of patients with eosinophilic pneumonia. PMID: 24111618
17. CIP4 is expressed at abnormally high levels in CLL cells, where it is required for CCL19-induced chemotaxis. PMID: 23644527
18. Serum CCL19 measurement serves as a new hallmark of the B cell-mediated rheumatoid arthritis subtype and may predict clinical response to rituximab. PMID: 23740460
19. High expression of CCL19 was identified as a good prognostic factor for lung adenocarcinoma. PMID: 23922113
20. Research suggests that CCL19 and CCL21 may not be associated with cervical lymph node metastasis or other clinical and microscopic factors in oral squamous cell carcinoma. PMID: 22976543
21. A novel signaling pathway has been identified that controls EDG-1 up-regulation following stimulation of T cells by CCR7 and CCL19. PMID: 22334704
22. CCL19 is implicated in AIDS patients with advanced immunodeficiency, potentially mediating both adaptive and maladaptive responses. PMID: 22288592
23. These results suggest a novel combinatorial guiding mechanism involving CCL19 and CCL21 for the migration and trafficking of CCR7 expressing leukocytes. PMID: 21464944
24. Increased expression of MIP-3alpha favors recruitment of immature DCs to the tumor bed, while de novo local expression of SLC and MIP-3beta induces accumulation of mature DCs at the tumor margin, forming clusters with T-cells. PMID: 20969772
25. Klebsiella pneumoniae-triggered DCs recruit human NK cells in a CCR5-dependent manner, leading to increased CCL19-responsiveness and activation of NK cells. PMID: 20865789
26. Nuclear localization of four and a half LIM domains 2 (FHL2) transgene is lost in mature, but not immature, bone marrow-derived dendritic cells following stimulation with CCL19. PMID: 20592280
27. Given the critical role of CCL19 in lymphocyte and dendritic cell trafficking, CCL19-binding competition by CRAM might be involved in modulating these processes. PMID: 20002784
28. CC chemokine CCL19 attracts mature T cells out of the fetal thymus organ culture. PMID: 11869682
29. Desensitizing concentrations of CCL21 and CCL19 had no significant effects on T lymphocyte transendothelial migration. PMID: 11870628
30. CCL19 is located in high endothelial venules, an appropriate location to induce transendothelial migration of CLL cells into lymph nodes. PMID: 11929789
31. Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21, and MIP-3beta/mCCL19: comparison to human CCX-CKR. (CCX-CKR) PMID: 11981810
32. Migration to CCL19 and CCL21 is dependent on phospholipase C and intracellular calcium flux but not on phosphatidylinositol-3 kinase. PMID: 14592837
33. CCL19 and CXCL12 play roles in the chemotaxis of mantle cell lymphoma B cells. PMID: 14871974
34. MIP-3beta was expressed in the human endometrium, but research did not strongly support the hypothesis that MIP-3beta is a potential chemoattractant for endometrial NK cells. PMID: 15019823
35. CCL19 migrated poorly towards GFP UCB or normal (NL) BM CD34+ cells, p210 UCB, and CML CD34+ cells. PMID: 15674360
36. By conditioning naive T cells into a motile dendritic cell-scanning state, CCL19 promotes antigen-independent responses and increases the probability of cognate histocompatibility complex (MHC)-peptide encounter. PMID: 16081805
37. Nitric oxide (NO) donor NOR4 provides a signal allowing LPS-stimulated DCs to migrate towards CCL19. PMID: 16249377
38. The maturation, in vitro migration, and cytokine production of human DC after stimulation with live H. pylori are reported. PMID: 16500130
39. The CCL19,CCL21/CCR7 chemokine system is expressed in inflamed muscles of polymyositis and may be involved in the pathogenesis of polymyositis. PMID: 16887149
40. Despite sharing only 25% sequence identity with CCL21, the amino terminal hexapeptide of CCL19 is capable of performing an in vitro role similar to that of CCL21, resulting in G protein activation of the CCR7 receptor. PMID: 16904643
41. CXCL13 and CCL19 cooperatively induce significant resistance to TNF-alpha-mediated apoptosis in acute and chronic B cell leukemia CD23+CD5+ B cells, but not in the cells from cord blood. PMID: 17082584
42. Expression of the CCL19 gene is regulated by a combined action of several members of the NF-kappaB, IRF, and STAT family transcription factors. PMID: 17182562
43. The abundance of CD83+ plasmacytoid dendritic cells (DCs) in perivascular areas and the overexpression of CCL19 and CCL21 in perivascular cellular foci suggest plasmacytoid DCs are central to the muscle inflammation in juvenile dermatomyositis. PMID: 17469160
44. These findings suggest hitherto unknown roles of SMAD transcription factors and of CCL19 in the elicitation phase of allergic contact dermatitis. PMID: 17597826
45. CCL19 plus CXCL13 regulate interaction between B-ALL CD23+CD5+ B cells and CD8+ T cells by inducing activation of PEG10, in turn, resulting in IL-10 overexpression and impairment of tumor-specific cytotoxicity in syngeneic CD8+ T cells. PMID: 17709502
46. This study suggests that CCL19 plays a role in both the physiological immunosurveillance of the healthy CNS and the pathological maintenance of immune cells in the CNS of MS patients. PMID: 17825430
47. After HIV-1 infection of CCL19- or CCL21-treated CD4(+) T-cells, low-level HIV-1 production but high concentrations of integrated HIV-1 DNA, approaching that seen in mitogen-stimulated T-cell blasts, was observed. PMID: 17881634
48. CCL19, CCL20, and CCL22 factors could play an additive role in the pathogenesis of the inflammatory process leading to bronchiolar fibro-obliteration in lung transplant patients. PMID: 18047937
49. Experiments performed to investigate the survival, adhesion, and metalloproteases secretion indicate that CXCL13 combined with CCL19 and CCL21 mainly affects the chemotaxis of Sezary syndrome cells. PMID: 18757429
50. Complement C1q chemoattracts human dendritic cells and enhances migration of mature dendritic cells to CCL19 via activation of AKT and MAPK pathways. PMID: 18838169

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HGNC: 10617

OMIM: 602227

KEGG: hsa:6363

STRING: 9606.ENSP00000308815

UniGene: Hs.50002