CCR7 Antibody, HRP conjugated

1. Research indicates that chemokine (C-C motif) receptor 7 (CCR7) plays a significant role in promoting metastasis of triple-negative breast cancer (TNBC) and could potentially serve as a target for breast cancer diagnosis and treatment. PMID: 30032244
2. Elevated CCR7 expression has been correlated with metastasis in urinary bladder cancer. PMID: 28534984
3. Studies suggest that CCL19/CCR7 contributes to the proliferation and invasion of endometrial stromal cells (ESCs) by activating the PI3K/Akt pathway, potentially contributing to the development of endometriosis. PMID: 28856757
4. Research has demonstrated that chemokines CCL19, CCL21, and CCR7 are crucial in bone destruction by enhancing osteoclast migration and resorption activity, a mechanism linked to rheumatoid arthritis pathogenesis. PMID: 28729639
5. Expression of CXCR4, CCR7, VEGF-C, and VEGF-D might have synergistic effects on lymph node metastasis in patients with cervical cancer. PMID: 28535405
6. Patients with acute graft-versus-host disease (aGvHD) exhibited higher percentages of CD4+CCR7+ T-cells in donor T-cells, while those with chronic GvHD (cGvHD) received higher percentages of CD8+CCR7+ T-cells. Functional experiments revealed that CCR7+ T-cells demonstrated greater activation potential compared to CCR7- T-cells. PMID: 28112745
7. These results suggest that CCL21/CCR7 may activate epithelial-mesenchymal transition (EMT) in lung cancer cells through the ERK1/2 signaling pathway. PMID: 28487957
8. CCL21/CCR7 interaction has been shown to facilitate NK cell adhesion to endothelial cells (ECs) and its reduction by hypoxia. PMID: 28416768
9. Research indicates that miR-1275 can positively regulate CCR7 expression in squamous cell carcinoma of the head and neck (SCCHN) through various mechanisms. PMID: 29278769
10. Studies provide evidence that CCR7 mediates EMT progression through the AKT pathway, highlighting its crucial role in breast cancer progression. PMID: 28378417
11. An increased percentage of peripheral CCR7 T cells accompanied by endothelial dysfunction has been reported in patients with ankylosing spondylitis. PMID: 28421995
12. Analysis of gene amplification and mRNA levels revealed that CCR7 expression in breast cancer correlated with a better prognosis. PMID: 28930757
13. Research indicates that CCR7 mediates TGF-beta1-induced MMP2/9 expression through NF-kappaB signaling. PMID: 28817313
14. Studies have shown that leukocyte subsets express distinct patterns of CCR7 sialylation, which contribute to receptor signaling and fine-tuning chemotactic responses. PMID: 26819318
15. Stimulation of the tumor microenvironment was observed to down-regulate the migration of CCR7-expressing tumor cells toward CCL21 and inhibit the formation of directional protrusions toward CCL21 in a novel 3-dimensional hydrogel system. PMID: 26936935
16. CCR7 expression levels in human tumors have been correlated with signatures of CD141(+) DC, intratumoral T cells, and better clinical outcomes. PMID: 27424807
17. Research suggests a specific role for CCL21/CCR7 in promoting EMT and metastasis in CD133+ pancreatic cancer stem-like cells. PMID: 27505247
18. This study indicated that CCR7 is overexpressed in CD4(-) CD8(-) thymocytes of myasthenia gravis patients. PMID: 26616645
19. High tumoral CCR7 expression was correlated with potential lymphatic involvement and poor prognosis in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors. PMID: 28114889
20. Results show that upregulation of CCR7 promotes cell proliferation and inflammation in A549 non-small cell lung cancer cells. However, silencing of CCR7 via siRNA treatment promotes cell apoptosis and suppresses the inflammatory response and TGF-beta1-induced EMT, which may be associated with NF-kappaB signaling. PMID: 28339080
21. Down-regulating CCR7 expression in MG63 cells could significantly inhibit cell proliferation, migration, and invasion abilities of MG63 cells, and also induce cell apoptosis. PMID: 27916085
22. These results suggest that upregulation of rat CCR7 expression does not alter the phenotype, differentiation, or proliferation capacity of human adipose-derived stem cells (hASCs), but does enable efficient migration of hASCs to rat secondary lymphoid organs. PMID: 28035134
23. CCL21/CCR7 interaction contributes to the time-dependent proliferation of papillary thyroid carcinoma (PTC) cells by upregulating cyclin A, cyclin B1, and cyclin-dependent kinase 1 (CDK1) expression through the extracellular signal-regulated kinase (ERK) pathway associated with iodine. PMID: 27574129
24. Research suggests that the CCR7 gene locus harbors a polymorphism that modifies the risk of myocardial infarction (MI) in patients with coronary artery disease (CAD). Further validation of this association could be sought in a prospective cohort of initially healthy individuals. PMID: 27317472
25. This study shows that plasmacytoid dendritic cells from rheumatoid arthritis patients exhibit high expression levels of CCR7. PMID: 27421624
26. This study suggests that NRP1 expression and lymphatic vessel density (LVD) are independent factors that are likely to predict the risk of lymph node (LN) metastasis in squamous cell carcinoma (SCC) of the tongue, whereas the expression of VEGFC, VEGFR3, CCR7, and SEMA3E are non-independent predictive factors. PMID: 27666723
27. Elevated CCR7 expression has been associated with gastric cancer. PMID: 26984468
28. The CCR7 pathway up-regulates Twist expression through ERK and PI3K/AKT signaling to manage the epithelial-mesenchymal transition of pancreatic ductal adenocarcinoma. PMID: 26219899
29. Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages. PMID: 26923638
30. High CXCR4 expression in primary breast tumors (PTs) was found to be associated with luminal A type tumor, suggesting a more favorable outcome. In contrast, CCR7 and FOXP3 expressions in PTs represented luminal B tumors, pointing to a more aggressive tumor behavior. Maspin expression did not differ between luminal types. PMID: 28011488
31. Results indicated that CCR7 is overexpressed in gallbladder cancer tissues and its expression correlates with staging and lymph node metastasis. PMID: 27009073
32. CCL21/CCR7 induce VEGF-D up-regulation and promote lymphangiogenesis through the ERK/Akt pathway in lung cancer. PMID: 26884842
33. The study demonstrated that down-regulation of CCR7 reduced proliferation, cell cycle progression, cell migration, and invasion in prostate cancer cells. PMID: 26722441
34. Findings suggest that MUC1 plays a significant role in CCL21-CCR7-induced lymphatic metastasis and could serve as a therapeutic target in esophageal squamous cell carcinoma. PMID: 26667143
35. Membrane-associated PGES1-dependent release of PGE2 is accompanied by elevated CCR7 expression in colon cancer cells. PMID: 26352871
36. Pyk2 is a key downstream signaling molecule of CCR7 in SCCHN, promoting SCCHN tumorigenesis and progression. PMID: 26352169
37. The CCR7 axis mediates TGF-beta1-induced EMT through crosstalk with NF-kappaB signaling, facilitating lymph node metastasis and poorer overall survival in patients with gastric cancer. PMID: 26176983
38. Blockade of CCR7, or treatment with a p38 MAP kinase inhibitor, reduced lymphatic dissemination of epithelial-mesenchymal transition cells. PMID: 25961925
39. Findings suggest that circulating memory Tfh cells, particularly CCR7+ICOS+ memory Tfh cells, may be associated with the relapse of multiple sclerosis (MS) and could potentially serve as a novel therapeutic target. PMID: 26231034
40. The chemotactic interaction between CCR7 and its ligand, CCL21, may be a critical event during progression in pancreatic cancer. PMID: 21594558
41. CrkL regulates CCL19 and CCR7-induced epithelial-to-mesenchymal transition via the ERK signaling pathway in epithelial ovarian carcinoma patients. PMID: 25636509
42. Recycling accounts, to a major extent, for the high levels of surface CXCR4/CCR7 on chronic lymphocytic leukemia (CLL) cells. Increased CCR4/CCR7 is detectable not only in circulating leukemic cells, but also in secondary lymphoid organs of CLL patients with lymphoadenopathy. PMID: 26282174
43. In specific donor/recipient pairs, KIR2DS4 expression may contribute to potentiating natural killer cell function by increasing both cytotoxicity and CCR7 expression on their surface. PMID: 25961063
44. Data indicate that inhibition of TGF-beta-activated protein kinase 1 (TAK1) reduces chemokine (C-C motif) receptor 7 (CCR7) expression. PMID: 25557171
45. The CCL21/CCR7 pathway activates signaling to up-regulate the Slug pathway, leading to the occurrence of the epithelial-mesenchymal transition process in human chondrosarcoma. PMID: 25556164
46. The study suggested that CCR7 promotes Snail expression to induce the epithelial-mesenchymal transition, resulting in cell cycle progression, migration, and invasion in gastric cancer. PMID: 25572817
47. High CCR7 expression was associated with colorectal cancer metastasis. PMID: 26179425
48. The solution structure of CCL19 has been reported. It contains a canonical chemokine domain. Chemical shift mapping shows that the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19, and binding is competitive. PMID: 26115234
49. These results reveal a significant crosstalk between CCR7 and VEGF-C and suggest a novel role of the CCL21/CCR7 chemokine axis in the promotion of breast cancer-induced lymphangiogenesis. PMID: 25744065
50. High expression of CCR-7 is associated with atherosclerotic arteries. PMID: 25318003

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HGNC: 1608

OMIM: 600242

KEGG: hsa:1236

STRING: 9606.ENSP00000246657

UniGene: Hs.370036