CCX3 Antibody

Introduction to Chemokine Receptors and Antibodies

Chemokine receptors are crucial in the immune system, facilitating the migration of immune cells to sites of inflammation. They are classified into several families, including CC, CXC, CX3C, and XC. Antibodies targeting these receptors can modulate immune responses and are being explored for therapeutic applications.

Overview of CCR3 and Its Antibodies

The CC chemokine receptor 3 (CCR3) is a receptor for several CC chemokines, including CCL5/RANTES, CCL7/MCP-3, and CCL11/eotaxin. It is expressed on eosinophils, basophils, a subset of Th2 lymphocytes, mast cells, and airway epithelial cells. CCR3 plays a significant role in allergic diseases such as asthma and ocular allergies.

Research Findings on CCR3 Antibodies

• Eosinophilic Inflammation Reduction: Anti-CCR3 antibodies have been shown to reduce eosinophilic inflammation significantly. In mouse models, these antibodies decreased the number of eosinophils in peripheral blood and intestinal mucosa, thereby reducing tissue damage associated with eosinophilic inflammation .

• Epitope Mapping: Studies have identified specific epitopes on the CCR3 receptor recognized by monoclonal antibodies. For example, the N-terminal region of mouse CCR3 is crucial for the binding of certain monoclonal antibodies .

Overview of CX3CR1 and Its Antibodies

The CX3C chemokine receptor 1 (CX3CR1) is involved in the migration of immune cells and cancer cells. It interacts with its ligand, CX3CL1 (fractalkine), which is a chemoattractant for cells expressing CX3CR1.

Comparison of Chemokine Receptor Antibodies