CD1E Antibody
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Product Specs
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA, and 0.02% sodium azide.
Form
Liquid
Lead Time
Typically, we can dispatch the products within 1-3 business days after receiving your orders. Delivery time may vary depending on the purchasing method or location. Please consult your local distributors for specific delivery time information.
Synonyms
CD_antigen=CD1e antibody; CD1A antibody; CD1e antibody; CD1e antigen antibody; CD1E antigen; e polypeptide antibody; CD1e molecule antibody; CD1E_HUMAN antibody; Differentiation antigen CD1-alpha-3 antibody; hCD1e antibody; Leukocyte differentiation antigen antibody; R2 antibody; R2G1 antibody; sCD1e antibody; soluble antibody; T-cell surface glycoprotein CD1e antibody; T-cell surface glycoprotein CD1e; membrane-associated antibody; T-cell surface glycoprotein CD1e; soluble antibody
Target Names
Uniprot No.
Target Background
Function
CD1e, a T-cell surface glycoprotein, exists in a soluble form that binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids. This binding is essential for the presentation of glycolipid antigens on the cell surface. The membrane-associated form of CD1e is not active.
Gene References Into Functions
- A study revealed no association between polymorphisms in CD1E genes and susceptibility to Guillain-Barre syndrome. PMID: 27653862
- The interaction between LAPTM5 and CD1e, along with their colocalization in antigen processing compartments, suggests a potential influence of LAPTM5 on CD1e's role in presenting lipid antigens. PMID: 22880058
- Within the late endosomes/lysosomes of dendritic cells, the acidic pH promotes the binding of lipid antigens to CD1e by enhancing hydrophobic and ionic interactions. PMID: 21481186
- Research indicates that allelic variation in CD1E does not significantly influence multifocal motor neuropathy susceptibility. PMID: 22003931
- CD1e can potentially modulate lipid presentation by CD1b, CD1c, and CD1d, exerting either positive or negative effects. PMID: 21844346
- Findings support the notion that CD1e may have evolved to mediate lipid-exchange/editing processes. PMID: 21788486
- Substitutions leading to amino acid changes at positions 73 and 77 of the alpha1 domain and at position 30 of the alpha2 domain suggest that the CD1E gene exhibits greater polymorphism than previously recognized. PMID: 12144626
- Cellular and biochemical properties of human and simian CD1e molecules are similar, indicating that the specific intracellular distribution of CD1e is crucial for its physiological and/or immunological functions. PMID: 12671734
- CD1e is involved in the processing of mycobacterial antigens hexamannosylated phosphatidyl-myo-inositols (PIM6). This process suggests that CD1e expands the repertoire of glycolipidic T cell antigens through glycolipid editing, thereby optimizing the immune response. PMID: 16311334
- Data indicate that ubiquitination of CD1e triggers its exit from Golgi compartments and its transport to endosomes. PMID: 18208508
- A polymorphism linked to the ability of the CD1E molecule to participate in the immune response to complex glycolipids has been identified. This polymorphism may be associated with altered immune responses to complex glycolipid antigens in certain individuals. PMID: 18325888
- The conservation of the CD1e propeptide throughout evolution suggests that it may play a role in optimizing the generation of CD1e molecules in other species. PMID: 19196239
Database Links
Subcellular Location
[T-cell surface glycoprotein CD1e, membrane-associated]: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.; [T-cell surface glycoprotein CD1e, soluble]: Lysosome lumen.
Tissue Specificity
Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.
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