CD300LG Antibody

Biological Functions

CD300LG serves as a dual-function mediator in immune responses:

Key Roles:

• Lymphocyte Trafficking: Facilitates L-selectin-dependent rolling and ICAM-1-mediated adhesion on high endothelial venules (HEVs) .

• Transendothelial Migration (TEM): Promotes lymphocyte transmigration through endothelial cells via Ig domain interactions .

• Immune Modulation: Downregulated in tumor microenvironments but upregulated in chronic inflammation, suggesting context-dependent roles .

Mechanistic Insights:

• Mucin Domain: Supports lymphocyte rolling via glycosylation-dependent interactions .

• Ig Domain: Binds ICAM-1 independently of LFA-1/VLA-4 pathways, enabling adhesion under shear stress .

Research Applications of CD300LG Antibodies

CD300LG antibodies are widely used in immunological and oncological studies:

Therapeutic Potential

Emerging evidence highlights CD300LG’s role in cancer immunotherapy:

• CIK Cell Enhancement: Induction of CD300LG-γ in cytokine-induced killer (CIK) cells significantly improves cytotoxic activity against tumor cells (e.g., K562 leukemia line) .

• Immune Escape Regulation: Reduced CD300LG expression in lung cancer correlates with tumor immune evasion, suggesting therapeutic targeting potential .

Research Limitations and Future Directions

While CD300LG antibodies have advanced understanding of lymphocyte-endothelial interactions, challenges remain:

• Glycoform Specificity: Commercial antibodies may not distinguish between differentially glycosylated isoforms .

• Therapeutic Validation: In vivo studies are needed to confirm CD300LG’s efficacy in enhancing adoptive cell therapies .