CD3E Antibody

• The ionic CD3-epsilon -Lck interaction regulates the phosphorylation level of the T-cell receptor. PMID: 28659468
• A novel pathogenic frameshift variant of the CD3E gene has been identified in two unrelated T-B+ NK+ severe combined immunodeficiency infants from Turkey. PMID: 28597365
• The stalk domains of NKp30 and NKp46, other NCRs utilizing CD3zeta for signaling, were not interchangeable without significant deficiencies in folding, plasma membrane targeting, and/or ligand-induced receptor signaling. PMID: 27754869
• The inducible recruitment of WASp to the TCR-CD3 complex is partially dependent on tyrosine phosphorylation of Cd3e. PMID: 26342115
• Our findings suggest that the change in CD3zeta-chain expression from the baseline is an independent predictor of residual and recurrent head and neck squamous cell carcinoma. PMID: 26888626
• Data suggest that HIV-1 gp41 transmembrane domain (TMD) directly interacts with TMDs of the T-cell receptor and its CD3-antigen co-receptors (delta, gamma, and epsilon). These interactions may be involved in the immune evasion mechanism of HIV-1. PMID: 26828096
• Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and the Nck-CD3epsilon interaction could be a target for pharmacological modulation of the immune response. PMID: 24470497
• ABCB1 homozygous 3435 TT carrier subjects exhibited the lowest Pgp activity compared with 3435 CT and CC carriers in renal transplant patients. PMID: 23216707
• Local alterations in the lipid composition of TCR microclusters make the CD3epsilon cytoplasmic domain accessible during the early stages of T cell activation. PMID: 23166358
• Levels of CD3epsilon, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict the risk for new basal cell carcinomas. PMID: 21980389
• Analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon transgenic mice. PMID: 21203507
• Results indicate that the generation of CD3varepsilon chain isoforms with different N-terminal sequence and pI is a common occurrence. PMID: 19616027
• Nck recruitment by CD3 epsilon reveals a ligand-induced conformational change crucial for T cell receptor signaling and synapse formation. PMID: 12110186
• The T cell receptor can be recruited to a subset of plasma membrane rafts, independent of cell signaling and associated with raft clustering. PMID: 12499387
• SCID is caused by a CD3E deficiency. PMID: 15546002
• CD3 expression was strong in normal proximal and distal tubular epithelium and in renal oncocytomas, weak in chromophobe carcinoma, and absent in clear cell carcinomas, papillary renal cell carcinoma, and a transitional cell carcinoma. PMID: 16308105
• The CD3 epsilon immune recognition receptor cytoplasmic domain binds to acidic and mixed phospholipid vesicles with a binding strength that correlates with the protein net charge and the presence of clustered basic amino acid residues. PMID: 17176095
• The CD3epsilon-mediated signal transduction pathway is essential for this transformation process. PMID: 17507663
• Notch-dependent cytoplasmic CD3 expression can only be achieved during the early phase of NK-cell differentiation. PMID: 17630354
• In lung adenocarcinoma patients, significant decreases in MFI values for CD3epsilon, but not CD3zeta, were observed in CD4+T and CD8+T cells from pleural effusion compared to peripheral blood and in peripheral blood of patients compared to healthy donors. PMID: 17668204
• Data show that Nck forms a complex with an atypical PxxDY motif of the CD3epsilon tail, which encompasses Tyr166 within the activation motif and a T-cell receptor endocytosis signal. PMID: 18555270
• Results revealed that anti-CD3 monoclonal antibody (MAb)-mediated chimpanzee T-cell activation is a function of the anti-CD3 MAb isotype and is not governed by Siglec expression. PMID: 18667496
• Studies revealed that the human CD3 epsilon subunit forms a homodimer structure, providing insight into our understanding of the molecular assembly of the CD3 molecular complex. PMID: 19724882

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HGNC: 1674

OMIM: 186830

KEGG: hsa:916

STRING: 9606.ENSP00000354566

UniGene: Hs.3003