CDC48A Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (Made-to-order)
Synonyms
CDC48A antibody; CDC48 antibody; At3g09840 antibody; F8A24.11Cell division control protein 48 homolog A antibody; AtCDC48a antibody
Target Names
CDC48A
Uniprot No.
Target Background
Function
CDC48A likely plays a crucial role in cell division and growth. It interacts with specific SNARE proteins, participating in homotypic membrane fusion events—the fusion of vesicles derived from the same organelle.
Gene References Into Functions
CDC48A Function: Evidence from Literature
- As an AAA ATPase, AtCDC48A is implicated in processing polyubiquitinated NLR substrates, preparing them for degradation by the 26S proteasome. (PMID: 27340941)
- Studies suggest that the CDC48A(NPL4) complex actively removes sumoylated CenH3 from centromeres, disrupting centromeric heterochromatin and releasing bulk rRNA genes into the nucleolus for ribosome biogenesis. (PMID: 25344531)
- In Arabidopsis thaliana, CDC48 is upregulated upon infection. It interacts with MP within endoplasmic reticulum inclusions (dependent on the MP N-terminus) and facilitates MP protein degradation. (PMID: 23027663)
- Fluorescence correlation spectroscopy has demonstrated that CDC48A hexamers exist within larger protein complexes. (PMID: 17693538)
- CDC48A is essential for cytokinesis, cell expansion, and differentiation in plants. (PMID: 18660433)
Database Links
Protein Families
AAA ATPase family
Subcellular Location
Nucleus. Cytoplasm, cytoskeleton, phragmoplast. Cell membrane; Peripheral membrane protein. Note=Primarily localized to the nucleus and, during cytokinesis, to the phragmoplast, a site where membrane vesicles are targeted in the deposition of new cell wall materials.
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