CD5 Antibody
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Product Specs
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze/thaw cycles.
Lead Time
Typically, we can ship the products within 1-3 business days of receiving your order. Delivery times may vary depending on the purchasing method or location. Please consult your local distributors for specific delivery timeframes.
Synonyms
CD5; LEU1; T-cell surface glycoprotein CD5; Lymphocyte antigen T1/Leu-1; CD antigen CD5
Target Names
Uniprot No.
Target Background
Function
CD5 may act as a receptor in regulating T-cell proliferation.
Gene References Into Functions
- These findings support the notion that CD5 is not only a phenotypic marker but a relevant player in CLL cell biology. Germline-defined functional CD5 variants influence CLL outcome. PMID: 26991857
- ZAP70 is the only gene differentially expressed in CD5-high and CD5-low normal B-lymphocytes, confirming the crucial role of Zap-70 tyrosine kinase in BCR signaling alterations in B-CLL. PMID: 29125235
- High CD5 plasma levels in patients with severe ASD suggest a potential involvement of CD5 in the physiology of autism. However, further investigation with larger populations is needed to determine whether elevated CD5 levels are a consequence of autism or play a pathogenic role. PMID: 28406773
- A CD34-negative MYC-rearranged B-lymphoblastic lymphoma aberrantly expresses CD3 and CD5. PMID: 28280048
- This study provides insights into the regulation of CD5 expression on leukemic T cells, potentially aiding in understanding the molecular mechanism of CD5 down-regulation. PMID: 28752543
- CD5 transcription is increased, resulting in the production of three mRNA isoforms by APA, all contributing to protein production at different levels. PTBP1 binds in the vicinity of pA1, leading to an increase in mRNA levels, and miR-204 targets the longer CD5 mRNA. PMID: 27005442
- High CD5 expression is associated with lymphoma in Waldeyer ring. PMID: 27616053
- Trans-signaling of IL-6 can only occur via sIL-6R, but not sCD5. PMID: 28159554
- The majority of CD5(low) B cells in patients are leukemic, identifying CD5(low) B cells as a significant component of CLL. This finding has implications for CLL pathogenesis, clinical monitoring, and the development of anti-CD5-directed therapies. PMID: 27693386
- The CD5 Pro224-Ala471 haplotype in homozygosis improved melanoma survival in the entire set of patients. These findings highlight the relevance of genetic variability in immune-related genes for clinical outcome in melanoma. PMID: 27169428
- R-EPOCH therapy does not seem to impact the known poorer prognosis of patients with de novo CD5+ diffuse large B-cell lymphoma, and CD5 expression remains an independent prognostic factor in R-EPOCH-treated patients with diffuse large B-cell lymphoma. PMID: 28039906
- CD5+B lymphocytes were increased and activated in autoimmune hemolytic anemia patients. PMID: 26968550
- This study confirms the poor prognosis of de novo CD5+ DLBCL in a large multi-center cohort despite initial rituximab-containing chemotherapy and suggests that stem cell transplantation fails to salvage the majority of these patients. PMID: 26800311
- 5.2% were positive for CD5 and 5.7% positive for epstein-Barr virus encoded RNA. PMID: 26369546
- CD5 polymorphisms are associated with systemic lupus erythematosus. PMID: 25402503
- Three tyrosine-based domains within the CD5 cytoplasmic tail promote T-cell survival through non-overlapping mechanisms. PMID: 26363459
- A case of mantle cell lymphoma with a unique pattern of CD5 negative to positive expression switching in relapse. PMID: 24166616
- CD5 expression is useful in distinguishing thymic carcinoma from poorly differentiated lung carcinoma. PMID: 23958552
- The proportion of CD5+ B cells at 1 month of age is inversely correlated with total IgG levels at 18 and 36 months of age. PMID: 24928995
- Down-regulation of CD5 on activated CD8(+) T cells may serve as a useful marker of dysregulated T cell activation and proliferation in FHL2. PMID: 24051121
- CD5 expression in nodal marginal zone lymphoma correlates with a higher frequency of dissemination, but patients have an indolent clinical course and excellent overall survival. PMID: 24124149
- Our results indicate that CD5(+) B cell subsets might be associated with the pathogenesis of SPMS. PMID: 22732449
- Functional CD5-dependent casein kinase 2 signaling is necessary in a CD5 knock-in mouse for efficient differentiation of naïve CD4+ T cells into T helper (Th)2 and Th17 cells, but not Th1-type cells. PMID: 22904299
- Case Report: CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung. PMID: 22333190
- Our results show that CD5 expression is rare in MALT lymphoma and is often associated with nongastric disease and an increased tendency to present with disseminated disease. PMID: 22406370
- Hepatitis C virus infection of human T lymphocytes is mediated by CD5. PMID: 22278227
- The primary carcinoma showing thymus-like elements of the thyroid frequently expresses KIT and CD5 proteins. PMID: 21835435
- Alternative costimulation via CD5, rather than classic costimulation via CD28, primes naïve T cells for stable Th17 development through promoting the expression of IL-23R. PMID: 21926348
- Post-thymic regulation of CD5 levels in human memory T cells is inversely associated with the strength of responsiveness to interleukin-15. PMID: 21539877
- Immunological significance of CD19 for the IL-10 production by CD5(+) B cells. PMID: 21786452
- Case Report: Describes the recurrence of CD5 positive MALT lymphoma in the oral cavity and compares the immunohistochemical expressions of CD5, lambda, and kappa between the primary and recurrent tumors. PMID: 21892966
- CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase. PMID: 21757751
- Conclude that high percentages of CD5+B cells independently associate with an increased risk of early conversion to multiple sclerosis in clinically isolated syndrome patients. PMID: 21436320
- Data show that CD5 expression is associated with NFAT2 activity and mildly STAT3 activity, indicating that CD5 controls IL-10 secretion. PMID: 21398617
- The full-length protein variant, encoded by E1A-cd5, translocates the phosphatase SHP-1 to the vicinity of the B-cell receptor, raises its threshold, and thereby limits the response of autoreactive B cells [review]. PMID: 21395509
- CD5-positive splenic marginal zone lymphoma may be related to memory B-cell neoplasm or plasma cell differentiation. PMID: 21123968
- Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report. PMID: 19901887
- CD5-negative regulation of B cell receptor signaling originates from tyrosine residue Y429 outside an immunoreceptor tyrosine-based inhibitory motif. PMID: 11751967
- Origins and functions of B-1 cells with notes on the role of CD5. Review. PMID: 11861604
- Multiple somatic mutations in human cancers. The value of the CD5 microsatellite as a marker for instability in different tumor types, particularly in B-cell leukemia and lymphoma. PMID: 11869933
- CD5 supports the survival of B cells by stimulating IL-10 production and by concurrently exerting negative feedback on BCR-induced signaling events that can promote cell death. PMID: 12393419
- CD5-negative, CD10-negative small B-cell leukemia: variant of chronic lymphocytic leukemia or a distinct entity. PMID: 12447961
- CD5 is rapidly recruited at the immunological synapse (IS) and lowers the T cell response elicited by antigen presentation by targeting downstream signaling events without affecting IS formation. PMID: 12707340
- The CD5+ diffuse large-B-cell lymphoma (DLBCL) constitutes a disease category distinct from that of CD5- DLBCL and other CD5+ malignancies. PMID: 14603444
- The 5'-flanking region of human CD5 is transcriptionally active in T cells, and Ets transcription factors in conjunction with other regulatory elements are responsible for constitutive and tissue-specific CD5 expression. PMID: 15187131
- Overexpression in these cells indicates disease progression in B-cell leukemia patients. PMID: 15549146
- CD5 is associated with receptor revision in activated mature B cells and likely to promote expression of suitable immunoglobulin gene receptors capable of initiating the germinal center reaction. PMID: 15843554
- The polymorphic CD5 promoter is associated with increased susceptibility to B-cell chronic lymphocytic leukemia and mantle cell lymphoma. PMID: 15981803
- The balance between the 2 alternative exons 1 might be central to the regulation of membrane CD5 in human B cells. PMID: 15998834
- Analysis of CD5-positive diffuse large B-cell lymphoma with the unusual phenotype of cytoplasmic CD20 (+), surface CD20 (-). [case report] PMID: 16923582
Database Links
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
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