CDON Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze/thaw cycles.
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your order. Delivery time may vary depending on the purchasing method or location. Please consult your local distributor for specific delivery times.
Synonyms
CDO antibody; Cdon antibody; CDON_HUMAN antibody; Cell adhesion molecule-related/down-regulated by oncogenes antibody
Target Names
Uniprot No.
Target Background
Function
CDON is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. It plays a crucial role in promoting the differentiation of myogenic cells.
Gene References Into Functions
- A novel heterozygous nonsense CDON mutation was identified in a case of Pituitary Stalk Interruption Syndrome, presenting with neonatal hypoglycemia and cholestasis. PMID: 26529631
- CDON is essential for the proliferation and survival of lung cancer cells through the Hedgehog (Hh) signaling pathway. PMID: 25369201
- Research suggests that CDON acts as a tumor suppressor in neuroblastomas, and its expression is tightly regulated by microRNAs. PMID: 25313246
- A single-nucleotide polymorphism in CDON has been associated with biochemical recurrence in prostate cancer. PMID: 24740842
- Mutations in the CDON gene are known to cause holoprosencephaly. (Review) PMID: 22326621
- CDON has been found to be overexpressed in prostate cancer. PMID: 21849809
- For effective signaling, CDON must associate with both ligands and other hedgehog-receptor components, particularly PTCH1. Disruptions in these interactions can lead to holoprosencephaly. PMID: 21802063
- Hedgehog proteins interact with CDON and its homolog, BOC (Brother of CDO), in a conserved manner. PMID: 20519495
- CDON and BOC are involved in the differentiation of cells in the skeletal muscle lineage. PMID: 12720294
- CDON and BOC form complexes with specific cadherins, mediating some of the promyogenic effects of cell-cell contact. PMID: 12634428
- Targeted inactivation of Cdon in mice results in mild holoprosencephaly, suggesting its involvement in signaling pathways, such as the Sonic hedgehog pathway, that control midline development. PMID: 12620190
Database Links
Involvement In Disease
Holoprosencephaly 11 (HPE11)
Subcellular Location
Cell membrane; Single-pass membrane protein.
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