CEBPD Antibody

• Gemcabene reduces C-reactive protein (CRP) levels through a C/EBPδ and NF-κB-mediated transcriptional mechanism, suppressing IL-6 and IL-1β-induced CRP production. PMID: 29644527
• Studies highlight CEBPD's role in the interplay between inflammation and lipid accumulation in M1 macrophages. PMID: 28859294
• The EGFR/STAT3 pathway contributes to cisplatin (CDDP)-induced CEBPD expression in UCUB cells. Gefitinib and S3I-201 treatment significantly reduces CEBPD expression and increases the sensitivity of CDDP-resistant UCUB cells to CDDP and paclitaxel. PMID: 27435393
• Research demonstrates a critical astrocytic CEBPD function and suggests miR-135a antagonists as potential therapeutic targets for Alzheimer's disease. PMID: 26208701
• Findings reveal a molecular mechanism by which ERα signaling reduces cancer cell aggressiveness and demonstrate the context-dependent functions of C/EBPδ in different cancers. PMID: 27181204
• CREB overexpression increases CCAAT-enhancer-binding protein-delta (C/EBPδ) levels, leading to myeloid differentiation arrest; silencing the CREB-C/EBPδ axis restores terminal differentiation. PMID: 27118402
• Data suggest that interleukin-1β (IL-1β) upregulates hepcidin expression in hepatocytes; inflammation induces IL-1β production; IL-1β upregulates CEBPD expression; and increased CEBPD upregulates hepcidin transcription. PMID: 28438835
• The C/EBPδ binding site is necessary for RU486-mediated activation of the CHOP promoter. PMID: 26174226
• Results suggest that CCAAT/enhancer binding protein delta (CEBPD) could serve as a valuable diagnostic marker and therapeutic target in hepatocellular carcinoma (HCC). PMID: 26358750
• CEBPD amplification and overexpression are associated with urothelial carcinoma. PMID: 26307680
• Knockdown of C/EBPδ expression in pericytes following immune stimulation increased chemokine and adhesion molecule expression. PMID: 26166618
• The CEBPD-hypoxia-inducible factor-1 (HIF-1) pathway is identified as a crucial HIF-1-regulating mechanism in tubular epithelial cells protecting against kidney injury. PMID: 25692954
• CK2 binds to C/EBPδ, potentially targeting CK2 to the transcriptional machinery for phosphorylation of other transcription factors or co-activators. PMID: 25680545
• Dysfunction in the Rho-associated kinase 2 (ROCK2)-p-GSK3β/β-catenin-CEBPD regulatory circuitry may contribute to hepatocellular carcinoma (HCC) tumorigenesis. PMID: 25771860
• GSK3β-mediated CEBPD phosphorylation in astrocytes plays a key role in microglia activation. PMID: 23993701
• The inflammatory PGE2-HuR-C/EBPδ axis in macrophages promotes tumor progression by inhibiting tumor cell phagocytosis and inducing immunosuppressive cytokine production. PMID: 23861541
• CEBPD inhibits FBXW7 expression and increases HIF-1α expression and activity under hypoxic conditions. PMID: 21076392
• CEBPD supports inflammatory signaling via TLR4 gene activation and is downregulated by FBXW7α following GSK-3β phosphorylation. PMID: 23575666
• Review article on CEBPD expression, regulation, and function, focusing on inflammation and cancer. PMID: 24155666
• The FRA8I fragile site, encompassing KIAA0146, CEBPD, and PRKDC, may be involved in colorectal cancer. PMID: 23603433
• CEBPD and its downstream effectors could potentially serve as biomarkers for rheumatoid arthritis (RA) diagnosis and therapeutic targets. PMID: 23028973
• This study first demonstrates the role of astrocytic CEBPD and the CEBPD-regulated molecule PTX3 in the accumulation of damaged neurons, a hallmark of Alzheimer's disease (AD) pathogenesis. PMID: 21112127
• Src kinase activity downregulates C/EBP-δ protein (but not mRNA) via a SIAH2 E3 ligase-dependent mechanism. PMID: 22037769
• A novel function of CEBP-δ in lymphangiogenesis through regulation of VEGFR3 signaling in lymphatic endothelial cells is described. PMID: 21666710
• C/EBPδ plays a role in late stages of keratinocyte differentiation. PMID: 21072181
• HMDB kills cancer cells through activation of CEBPD pathways. PMID: 20971808
• C/EBPδ and STAT-1 are required for TLR8 transcriptional activity. PMID: 20829351
• Common allelic variants in CEBPD were not associated with obesity phenotypes in healthy White Northern European families. PMID: 20460359
• C/EBPδ promotes monoubiquitination of FANCD2, essential for its function in replication-associated DNA repair. PMID: 20805509
• C/EBPδ expression may prevent meningioma recurrence by inhibiting neoplastic growth. PMID: 19806320
• CEBPD reduces cisplatin-induced reactive oxygen species and apoptosis by inducing copper/zinc-superoxide dismutase expression. PMID: 20385105
• NF-κB plays a crucial role in IL-1-induced C/EBPδ expression and subsequent acute-phase protein gene regulation. PMID: 19800021
• A single nucleotide polymorphism in the CEBPD gene was found in 2.9% of patients studied. PMID: 11851384
• Posttranscriptional and posttranslational regulation in G0 growth-arrested mammary epithelial cells. PMID: 12554732
• C/EBPδ expression in breast tumors correlated with clinicopathological parameters, ER/PR expression, Ki67 immunostaining, and cell-cycle regulatory protein expression. PMID: 12825852
• C/EBPδ abolishes CBP phosphorylation and transcriptional activation, impacting C/EBP-mediated transcription. PMID: 12857754
• AD tissue showed abundant C/EBPδ staining in astrocytes, particularly those surrounding amyloid-β deposits. PMID: 15212823
• The C/EBPδ gene is controlled at multiple levels, suggesting a role in cell cycle control and/or cell fate determination. PMID: 15389878
• Loss-of-function alterations in the pSTAT3/C/EBPδ growth inhibitory pathway are common in breast cancer cell lines. PMID: 15389879
• C/EBPδ is a downstream mediator of IL-6-induced growth inhibition in prostate cancer cells. PMID: 15486993
• C/EBPδ expression in BCR-ABL-positive leukemic cells induces neutrophil differentiation. PMID: 15674331
• IL-6 increases hepatic PAI-1 expression via the -232 to -210 bp promoter region containing a C/EBPδ binding site. PMID: 15718495
• The PI3-kinase/p38(MAPK)/CREB pathway contributes to EGF activation of NF-IL-6β gene expression. PMID: 15901830
• Small interfering RNA of C/EBPδ suppressed COX-2 expression, highlighting its role in COX-2 gene transcription. PMID: 16195339
• Reduced C/EBPδ gene expression is associated with breast tumors. PMID: 16322893
• IL-1 and IL-6 have similar effects on PAI-1 expression, but through distinct signaling pathways converging on C/EBPδ. PMID: 16914534
• Increased expression of GADD45A, BTG2, PDE4B, and CEBPD and downregulation of TOB1 were observed in skeletal muscle during intradialysis. PMID: 16997058
• C/EBPδ is a tumor suppressor gene in acute myeloid leukemia, often silenced by promoter methylation. PMID: 17234736
• C/EBPδ ubiquitination is not required for proteasome-mediated degradation. PMID: 17373909
• C/EBPδ promotes holoclone self-renewal and prevents clonal evolution in limbal stem cells. PMID: 17562792

HGNC: 1835

OMIM: 116898

KEGG: hsa:1052

STRING: 9606.ENSP00000386165

UniGene: Hs.440829