ced-8 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% ProClin 300
Components: 50% Glycerol, 0.01M PBS, pH 7.4
Components: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (Made-to-order)
Synonyms
ced-8 antibody; F08F1.5Cell death abnormality protein 8 antibody
Target Names
ced-8
Uniprot No.
Target Background
Function
CED-8 is a phospholipid scramblase that functions downstream of CED-9 and the caspase CED-3. Its activity promotes the externalization of phosphatidylserine on the surface of apoptotic cells. Phosphatidylserine serves as a specific marker and signal for the engulfment of these cells. CED-8 regulates the kinetics of apoptosis during embryonic development, but is not essential for the engulfment of germ cell corpses.
Gene References Into Functions
- Caspase activation leads to CED-8 activation, promoting apoptosis and phosphatidylserine externalization. PMID: 24225442
- As the sole C. elegans Xk-family homolog, CED-8 facilitates apoptotic phosphatidylserine exposure and subsequent cell corpse engulfment. Xk-family proteins play a conserved evolutionary role in promoting phagocytosis of dying cells by modifying plasma membrane phospholipid distribution. PMID: 23845944
Database Links
Protein Families
XK family
Subcellular Location
Cell membrane; Multi-pass membrane protein.
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