CFHR2 Antibody
Description
CFHR2 Protein Overview
CFHR2 is a 50 kDa plasma glycoprotein composed of four short consensus repeat (SCR) domains. Key features include:
CFHR2 shares 93% sequence identity with SCR19-20 of factor H but lacks competition for C3b binding, enabling cooperative regulation with factor H .
CFHR2 Antibody Validation Data
Commercially available CFHR2 antibodies demonstrate the following validation metrics:
Research Applications of CFHR2 Antibodies
Key experimental uses include:
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Immunohistochemistry: Localizing CFHR2 in glomerular dense deposits (C3 glomerulopathy)
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Functional assays: Quantifying CFHR2-mediated inhibition of C3 convertase activity
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Disease studies: Investigating CFHR2 polymorphisms (rs3790414) in AMD cohorts
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Protein-protein interaction: Analyzing CFHR2 binding to C3b/C3d via surface plasmon resonance
Key Research Findings Using CFHR2 Antibodies
Recent studies utilizing these antibodies have revealed:
Product Specs
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- Research suggests an association between the CFHR2-rs2986127 variant and acute anterior uveitis (AAU) diagnosis. PMID: 27306586
- Next-generation sequencing of the CFH region identified potentially functional variants (missense, splice site, and indel) on the four common haplotypes. Notably, we found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, unlike the liver, which serves as the primary source of circulating proteins, including CFHR2. PMID: 27196323
- CFHR2 likely works in conjunction with factor H, as CFHR2 inhibits convertases while simultaneously facilitating factor H-mediated convertase degradation by factor I. PMID: 24260121
- A hybrid CFHR2-CFHR5 plasma protein, resulting from a chromosomal deletion mutation, stabilizes the C3 convertase and reduces factor H-mediated convertase decay. PMID: 24334459
