che-1 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
che-1 antibody; C55B7.12Transcription factor che-1 antibody; Abnormal chemotaxis protein 1 antibody
Target Names
che-1
Uniprot No.
Target Background
Function
The CHE-1 transcription factor plays a crucial role in defining the identity of ASE chemosensory neurons. It activates the expression of genes specifically required for ASE chemosensory neuron function, including seven-transmembrane receptors and guanylate cyclase. Moreover, CHE-1 is essential for regulating the left/right asymmetry observed in ASE chemosensory neurons by controlling the expression of genes like *cog-1* and *ceh-36*.
Gene References Into Functions
- The *che-1* gene encodes a zinc finger transcription factor that is essential for the proper specification of chemosensory neurons. PMID: 12588839
- The ASE motif serves as a binding site for the C2H2 zinc finger transcription factor CHE-1, which is critical for the correct differentiation of the ASE gustatory neuron. PMID: 17606643
- Mutations within the cis-regulatory control region of *cog-1* affect a conserved binding site for the C2H2 zinc-finger transcription factor CHE-1. These mutations disrupt the left/right asymmetry observed in ASE neurons. PMID: 19189954
Database Links
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in ASE chemosensory neurons and in some other neurons.
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