CHX24 Antibody

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Description

Terminology Clarification

The term "CHX24" does not correspond to any recognized gene, protein, or antibody in biological nomenclature. Possible scenarios for this discrepancy include:

  • Typographical error: The query may reference a misspelled or misformatted term (e.g., CHD2, CHD4, or CXCL24).

  • Proprietary name: "CHX24" could be an internal code for an unpublished or commercial antibody not yet cataloged in public databases.

CHD2 Antibodies

CHD2 (Chromodomain Helicase DNA-Binding Protein 2) is a well-characterized epigenetic regulator. Key antibodies targeting CHD2 include:

AntibodyHostClonalityApplications (Dilution)Observed MWCitations
Proteintech #21334-1-APRabbitPolyclonalWB (1:1000–1:8000), IHC (1:50–1:500)230–250 kDa
Sigma-Aldrich HPA060744RabbitPolyclonalIF (0.25–2 µg/mL), IHC (1:200–1:500)Predicted: 211 kDa

Research Findings:

  • CHD2 antibodies are widely used in chromatin remodeling studies and neurological disorder research .

  • Validated in HEK-293, Jurkat, and K-562 cell lines .

CHD4 Antibodies

CHD4, a paralog of CHD2, is implicated in DNA repair and cancer. Notable antibodies:

AntibodyHostClonalityApplications (Dilution)Observed MWCitations
Cell Signaling #4245RabbitPolyclonalWB (1:1000)260 kDa
Abcam #ab72418RabbitPolyclonalWB, ICC/IF, IP218 kDa
Cell Signaling #12011RabbitMonoclonalWB (1:1000), IF (1:400–1:800)260 kDa

Functional Insights:

  • CHD4 antibodies detect isoforms involved in the NuRD complex, critical for gene silencing and DNA damage response .

Potential Contexts for "CHX24"

If the query refers to a novel or proprietary antibody, the following steps are recommended for verification:

  1. Reagent validation: Cross-check with manufacturers (e.g., Thermo Fisher, Abcam, CST) for unpublished catalog entries.

  2. Epitope mapping: Confirm if "CHX24" targets a specific domain (e.g., CHD2’s helicase region or CHD4’s chromodomain).

  3. Clinical relevance: Explore associations with diseases (e.g., cancer, neurodegenerative disorders) in preprint repositories like bioRxiv.

Product Specs

Buffer
Preservative: 0.03% Proclin 300
Composition: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
CHX24 antibody; At5g37060 antibody; MJG14.5Cation/H(+) antiporter 24 antibody; Protein CATION/H+ EXCHANGER 24 antibody; AtCHX24 antibody
Target Names
CHX24
Uniprot No.

Target Background

Function
May function as a cation/H(+) antiporter.
Database Links
Protein Families
Monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family, CHX (TC 2.A.37.4) subfamily
Subcellular Location
Membrane; Multi-pass membrane protein.
Tissue Specificity
Specifically expressed in pollen.

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