CIS1 Antibody
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Description
Applications of CIS1 Antibodies
CIS1 antibodies are widely used in protein detection and functional studies. Key applications include:
Key Antibody Reagents
Experimental Insights
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Western Blot: Detects CIS-1 in human lung/kidney tissues (28 kDa) and hematopoietic cell lines (35–40 kDa) .
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Immunocytochemistry: Localizes CIS-1 to the cytoplasm in Hodgkin’s lymphoma cells .
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Functional Studies: CIS-1 binds phosphorylated IL-3/EPO receptors, promoting STAT5 inactivation via proteasomal degradation .
Cancer Biology
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Drug Resistance: CIS-1 overexpression in gastric cancer cells enhances autophagy and resistance to chemotherapeutics like 5-fluorouracil .
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Prognostic Marker: Elevated CIS-1 levels correlate with poor survival in non-small cell lung cancer patients treated with osimertinib .
Signaling Pathways
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Constituents: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
CIS1 antibody; ATG31 antibody; AER409CAutophagy-related protein 31 antibody; Protein CIS1 antibody
Target Names
CIS1
Uniprot No.
Target Background
Function
CIS1 antibody plays a crucial role in starvation-induced autophagy. It is involved in mitophagy, a specific type of autophagy targeting mitochondria. CIS1, in collaboration with ATG17 and ATG29, functions at the preautophagosomal structure (PAS) to facilitate the formation of normal autophagosomes under starvation conditions. Additionally, CIS1 may contribute to microtubule function, including chromosome segregation and karyogamy.
Database Links
KEGG: ago:AGOS_AER409C
Subcellular Location
Cytoplasm, cytoskeleton. Preautophagosomal structure.
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