CIT Antibody

• This study provides evidence that ASPM, a microcephaly-associated protein, controls spindle orientation by regulating the dynamics of astral microtubules. CITK, a downstream effector of ASPM, is crucial for this activity. PMID: 27562601
• Eph kinase activity is essential for controlling abscission, the final stage of cytokinesis. Src and CITK act as downstream effectors in the Eph-induced signaling cascade. PMID: 27551053
• The striking phenotypic overlap between individuals with CIT mutations and knockout mice and rats deficient in the kinase domain supports the causal link between CIT mutations and primary microcephaly in humans. PMID: 27503289
• This study identified a splice site variant in CIT that is predicted to abolish the splice donor site. cDNA sequencing of an affected individual showed retention of an intron next to the splice donor site. This study revealed the first variant in the CIT causing Autosomal recessive primary microcephaly in the family. PMID: 27519304
• Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly PMID: 27453578
• This study identified recessively inherited pathogenic variants in CIT as the genetic basis of severe microcephaly and neonatal death. Postmortem data demonstrate that CIT is critical for building a normally sized human brain. PMID: 27453579
• CIT-K may promote the midbody formation by interacting with TUBB3 and by recruiting casein kinase-2alpha (CK2alpha) to the midbody. CK2alpha has been reported to phosphorylate the S444 residue of TUBB3. PMID: 26586574
• Proper midbody architecture requires cross-regulation between two cell division kinases: CITK and Aurora B, the kinase component of the chromosomal passenger complex. PMID: 27009191
• TPC1, a two-pore channel protein, was shown to interact with CITK. TPC1 overexpression affects RhoA activity and myosin light chain phosphorylation levels in cytokinesis. PMID: 25665131
• HIV-1 infection upregulates citK expression at the transcriptional level. PMID: 26524911
• These data suggest that the CC-domain-mediated translocation and actions of CITK ensure proper stabilization of the midbody structure during the transition from constriction to abscission. PMID: 23444367
• High CIT expression is associated with prostate cancer. PMID: 22761715
• p27, a cyclin-dependent kinase inhibitor, plays a role in cytokinesis by regulating CITK activity. PMID: 22293177
• CITK is a crucial abscission regulator that may promote midbody stability through active RhoA and anillin. PMID: 21849473
• Hrs, a protein involved in endocytosis, inhibits HIV-1 production by inhibiting CITK-mediated exocytosis. PMID: 21748597
• CITRON plays a role in the proliferation of hepatocellular carcinoma cells. PMID: 20369383
• There is evidence of statistical epistasis between DISC1, CIT, and NDEL1, genes associated with neurodevelopmental disorders, impacting the risk for schizophrenia. This finding is supported by functional neuroimaging studies. PMID: 20084519
• Citron-K exhibits a distinct cell cycle-dependent expression pattern and cellular localization as a downstream target of Rho-GTPase. It functions in the control of G(2)/M transition in the hepatocyte cell cycle. PMID: 12411428
• Single nucleotide polymorphisms in CIT have been associated with bipolar disorder. PMID: 15983625
• ASPM and CITK co-localize to the midbody ring during cytokinesis. PMID: 17534152

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HGNC: 1985

OMIM: 605629

KEGG: hsa:11113

STRING: 9606.ENSP00000376306

UniGene: Hs.119594