CKL7 Antibody
Shipped with Ice Packs 
In Stock 
Description
Clinical and Diagnostic Applications
CK7 antibodies are pivotal in tumor classification and metastatic origin determination:
Research Findings and Prognostic Implications
CK7 expression patterns and clinical outcomes have been extensively studied:
Colorectal Carcinoma (CRC)
Key Observations:
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CK7+ CRCs exhibit dedifferentiation, tumor budding, and micropapillary patterns .
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Prognostic relevance persists even in multivariate analysis, independent of stage or grade .
Lung Cancer
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Non-small cell lung cancer (NSCLC): Adenocarcinoma subtypes show CK7+ expression, while squamous cell carcinomas may be CK7- .
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Small cell lung cancer (SCLC): Rare CK7+ cases, but limited data .
Other Cancers
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Breast Cancer: CK7+ in ductal carcinomas; CK7- in lobular carcinomas .
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Urothelial Carcinomas: CK7+ correlates with poor prognosis in some studies .
Comparative Analysis of CK7 Antibodies
| Antibody | Strengths | Limitations |
|---|---|---|
| RM284 (Rabbit) | High specificity, validated in FFPE tissues | Limited species reactivity (human only) |
| EPR17078 (Rabbit) | Broad species compatibility (human/mouse/rat), batch consistency | Higher cost due to recombinant production |
| OV-TL12/30 (Mouse) | Low cross-reactivity, widely used in IHC | Requires optimization for WB |
| Polyclonal (NBP1-33104) | Broad epitope recognition | Lower specificity, background staining |
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Composition: 50% Glycerol, 0.01M PBS, pH 7.4
Composition: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
CKL7 antibody; At5g44100 antibody; MLN1.2Casein kinase 1-like protein 7 antibody; EC 2.7.11.1 antibody; Protein CASEIN KINASE I-LIKE 7 antibody
Target Names
CKL7
Uniprot No.
Target Background
Function
Casein kinases are enzymes characterized by their preference for acidic proteins, such as caseins, as substrates. They possess the ability to phosphorylate a wide range of proteins.
Gene References Into Functions
- AtCKL2 and AtCKL7 were found to be expressed in early developmental anthers under high temperature (HT) conditions. PMID: 30145767
Database Links
Protein Families
Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
Subcellular Location
Cytoplasm.
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