Clcn2 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% ProClin 300
Components: 50% Glycerol, 0.01M PBS, pH 7.4
Components: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 Week Lead Time (Made-to-Order)
Synonyms
Clcn2Chloride channel protein 2 antibody; ClC-2 antibody
Target Names
Clcn2
Uniprot No.
Target Background
Function
Clcn2 is a voltage-gated chloride channel. Chloride channels play crucial roles in various cellular processes, including cell volume regulation, membrane potential stabilization, signal transduction, and transepithelial transport. Clcn2 is specifically involved in regulating aldosterone production. In the glomerulosa cells, the opening of Clcn2 channels at hyperpolarized membrane potentials leads to cell membrane depolarization. This depolarization subsequently activates voltage-gated calcium channels, resulting in increased expression of aldosterone synthase, the rate-limiting enzyme in aldosterone biosynthesis.
Database Links
Protein Families
Chloride channel (TC 2.A.49) family, ClC-2/CLCN2 subfamily
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Tissue Specificity
Ubiquitously expressed.
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