CLCN4 Antibody
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Product Specs
Buffer
The antibody is provided as a liquid solution in phosphate-buffered saline (PBS) containing 50% glycerol, 0.5% bovine serum albumin (BSA), and 0.02% sodium azide.
Form
Liquid
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your order. The delivery time may vary depending on the purchasing method or location. Please consult your local distributor for specific delivery times.
Synonyms
Chloride channel 4 antibody; Chloride channel protein 4 antibody; Chloride channel; voltage sensitive 4 antibody; Chloride transporter ClC-4 antibody; ClC 4A antibody; ClC-4 antibody; CLC4 antibody; ClC4A antibody; CLCN4 antibody; CLCN4_HUMAN antibody; H(+)/Cl(-) exchange transporter 4 antibody; MGC163150 antibody
Target Names
CLCN4
Uniprot No.
Target Background
Function
This antibody targets CLCN4, a protein known for its strong outwardly rectifying, electrogenic H(+)/Cl(-) exchanger function. CLCN4 mediates the exchange of chloride ions against protons. It is a member of the CLC channel family, which encompasses both chloride channels and proton-coupled anion transporters that exchange chloride or other anions for protons. A characteristic feature of family members functioning as antiporters is the presence of conserved gating glutamate residues.
Gene References Into Functions
- Whole exome sequencing in a study identified de novo mutations in genes (KCNH5, CLCN4, and ARHGEF15) that were not previously associated with epilepsies in humans. PMID: 23647072
- The study examined the voltage dependence of uncoupled ClC-4 by protons and anions. PMID: 21354396
- Research indicated that CLCN4 is a novel driver of colon cancer progression. PMID: 20087350
- ClC-4, an intracellular chloride channel, stimulates copper incorporation into ceruloplasmin, likely by enhancing the efficiency of the ATP7B copper pump. PMID: 15057754
- In vivo studies revealed that coupled Cl-/H+ transport of ClC-4 and ClC-5 is of significant magnitude. PMID: 16034421
- Structural analysis of CLIC4 suggests that it can form a redox-regulated ion channel independently of any partner proteins. PMID: 16176272
- A specific sequence of amino acids (residues 14-63) at the N-terminus of hClC-4 serves as a novel motif essential for targeting both hClC-4 and other membrane proteins to the endoplasmic reticulum. PMID: 17023393
- The proposed mechanism involves anion-dependent conversion of ClC-type exchanger into an anion channel exhibiting typical characteristics of ClC anion channels. PMID: 19364886
- CLCN4 plays a role in vesicle acidification, exocytosis, endocytosis, and the secretory pathway. PMID: 10564087
Database Links
Involvement In Disease
Mental retardation, X-linked 49 (MRX49)
Protein Families
Chloride channel (TC 2.A.49) family, ClC-4/CLCN4 subfamily
Subcellular Location
Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
Tissue Specificity
Abundant in skeletal muscle and also detectable in brain and heart.
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