CLE43 Antibody

CD43 Protein Overview

CD43 (leukosialin, Ly48) is a 125–130 kDa sialoprotein expressed on hematopoietic cells, with critical roles in immune regulation . Key characteristics include:

Cellular Distribution

• High expression: T cells, neutrophils, macrophages, activated B cells

• Moderate expression: Dendritic cells, hematopoietic progenitors

• Pathological overexpression: Acute myeloid leukemia (AML), myelodysplastic syndrome (MDS)

Table 1: Key CD43 Antibody Clones

Functional Mechanisms

• Anti-adhesion: Antibody cross-linking disrupts CD43-moesin binding, enabling leukocyte migration

• Pro-apoptotic effects: Induces apoptosis in T cells and hematopoietic progenitors

• Therapeutic activity:

  • AT1413 mediates ADCC/CDC against AML blasts (EC50: 0.8–1.2 µg/ml)

  • 4D3 suppresses colorectal cancer metastasis by 67% in murine models

Table 2: CD43 Antibody Validation

Disease Associations

• Wiskott-Aldrich syndrome: CD43 dysregulation impairs leukocyte motility

• Leukemogenesis:

  • CD43s epitope expressed in 100% AML subtypes (n=62 patients)

  • JL1 epitope detection achieves 87% diagnostic accuracy in acute leukemia