Cleaved-CASP9 (D353) Antibody

1. CASP9 mutations have been linked to recurrent folate-resistant neural tube defects. PMID: 29358613
2. A study identified rare mutations in the apoptosis gene CASP9 in individuals with neural tube defects. The study demonstrated that the p.Y251C variant impairs the protein's apoptotic function, suggesting a loss-of-function mutation. It also showed that the p.R191G variant inhibited apoptosis under folate-deficient conditions, highlighting the significance of gene-environment interactions in this complex disease. PMID: 29365368
3. Research has indicated that caspase 9 and activated caspase 3 primarily regulate cell apoptosis in human dental pulp stem cells from deciduous teeth. PMID: 29845240
4. Low CASP9 expression has been associated with colorectal cancer. PMID: 29801534
5. Studies have shown that miR-96-5p, frequently upregulated in hepatocellular carcinoma (HCC), inhibits apoptosis by targeting CASP9. Therefore, miR-96-5p may be a potential therapeutic target for HCC. PMID: 29658604
6. Germline mutations in CASP9 may contribute to the susceptibility of developing gliomas in families with a Li-Fraumeni-like syndrome lacking a TP53 germline mutation. PMID: 27935156
7. The caspase 9 level was significantly lower and related to oxidant status in patients with polycystic ovary syndrome. However, the circulating levels of caspases 3 and 7 were statistically similar in both PCOS and control groups. PMID: 27899026
8. Research indicates that the apoptotic protease-activating factor 1 (Apaf-1) apoptosome activates caspase-9, partly through sequestration of the inhibitory caspase recruitment domains (CARDs) domain. PMID: 28143931
9. DES1 plays a crucial role in palmitic acid-mediated caspase 9 and caspase 3 activation. PMID: 27364952
10. CASP9 expression is associated with the inhibition of miR-182. PMID: 28298075
11. CASP-9 polymorphism has been associated with primary brain tumors. PMID: 28870924
12. High CASP9 expression is linked to lung tumorigenesis. PMID: 27197231
13. Knockdown of HMGI-C led to the significant induction of apoptosis via the mitochondrial pathway by inducing miR34a and cell cycle arrest in MDA-MB-468 cells in vitro. PMID: 27245202
14. Studies suggest that the formation of the apoptosome accompanied by the activation of caspase-9 may occur in brains affected by multiple system atrophy (MSA), and that a mitochondria-dependent apoptotic pathway may be partially involved in the pathogenesis of MSA. PMID: 27345387
15. Using recombinant proteins, a study investigated the influence of survivin on the inhibition of caspase-9 by XIAP in vitro. The study, using a fluorescence-based assay for apoptosome-stimulated activity of caspase-9, shows that survivin has no effect on the inhibition of caspase-9 by XIAP, neither in the presence nor absence of Smac. PMID: 27865841
16. Data show that caspase 9 (CASP9) single nucleotide polymorphism (rs1052576) TT genotype was associated with a higher risk of pathological stage. PMID: 28358701
17. The content of caspase 9 gene transcripts in peripheral blood leukocytes and plasma levels of TNF-alpha were significantly higher in healthy subjects carrying the C allele than in carriers of the GG genotype. PMID: 28091912
18. Results show that mRNA and protein levels of HAX-1 in prostate cancer cell lines were significantly higher and inhibit cell apoptosis through caspase-9 inactivation. PMID: 26323553
19. Renal CASP9 expression is increased in diabetes and increases as diabetic nephropathy progresses. PMID: 27141571
20. Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells. PMID: 26290316
21. Levels of caspase-9, caspase-10, MAVS, and pIRF7 in mononuclear cells and the disease activity index (SLEDAI) in patients with systemic lupus erythematosus were determined. PMID: 25370148
22. Expression of mutant caspase-9 correlated with a downregulation of BAFFR (B-cell-activating factor belonging to the TNF family (BAFF) receptor) in B cells and ICOS (inducible T-cell costimulator) in T cells. PMID: 25569260
23. Caspase-9 mediates Puma activation to determine the threshold for overcoming chemoresistance in cancer cells. PMID: 25356864
24. Phosphorylation of caspase-9 may be a valuable tool to assess the state of gastrointestinal cancer and the effects of anti-cancer therapy. PMID: 25031754
25. DNA fragmentation, DNA damage, caspase-9 activation, and a significant increase in the sub-G1 and S cell cycle phases confirmed the occurrence of apoptosis in a time-dependent manner. PMID: 24377517
26. Data indicate a significant association of two single nucleotide polymorphisms (SNPs) in caspase 9 (CASP9) and two haplotypes of the four SNP combinations with acute myeloid leukemia (AML) susceptibility. PMID: 24879622
27. Silica and double-stranded RNA (dsRNA) synergistically induce caspase-9-dependent apoptosis, but not inflammasome activation, of bronchial epithelial cells. PMID: 24661197
28. KAT5 RNAi may result in cleaved casp9 upregulation through p38MAPK activation in gallbladder carcinoma cells. PMID: 24427328
29. Overexpression of iASPP and low expression of caspase-9 in esophageal cancer are closely correlated with tumor invasion and metastasis. PMID: 24405603
30. The Atg7.caspase-9 complex performs a dual function of linking caspase-9 to the autophagic process while keeping in check its apoptotic activity. PMID: 24362031
31. The inhibitory effect of Ab42 on the apoptotic pathway is associated with its interaction with procaspase-9 and consequent inhibition of Apaf-1 apoptosome assembly. PMID: 24424093
32. The rs4645981 T allele and the rs4645981 T allele carrier might increase the risk of cancer, but the rs1052576 A allele, rs1052576 A carrier, rs2308941 T allele, and rs2308941 T carrier might be protective. PMID: 23479167
33. Interactions of caspase-9 with the BIR3 (baculovirus inhibitory repeat 3) exosite are essential for high-affinity binding. PMID: 23203690
34. In oligozoospermia, spermatogonia presented a significant increase in active caspase-9. PMID: 23359247
35. The change in caspase-9 expression from colon mucosa, adenoma to cancer suggests its potential involvement in the carcinogenesis of colon cancer. PMID: 24592539
36. dCas9 effectors can exert positive or negative regulation on the expression of developmentally relevant genes, which can influence cell differentiation status when impinging on a key node in the regulatory network that governs the cell state. PMID: 24346702
37. BIRC5-31CC and CASP9+83CT/TT genotypes were associated with an increased risk for renal cell carcinoma development in the female group of a southern European study population. PMID: 23645041
38. OSU-03012 induces apoptosis in human esophageal carcinoma cells through a p53/Bax/cytochrome c/caspase-9-dependent pathway. PMID: 23652278
39. EGCG, both alone and in combination with cisplatin, promoted the expression of the pro-apoptotic splice isoform of caspase 9. PMID: 23615977
40. The results demonstrated that 50 microg/mL beta-glucan significantly repressed the expression of the ERCC5 gene, did not change CASP9 expression, and induced the CYP1A1 gene. PMID: 23424205
41. CASP-9 polymorphisms are associated with susceptibility to low back pain during military training in Chinese soldiers. PMID: 23725396
42. Results found that polymorphisms of CASP9 and CASP10 genes may not contribute to CRC risk in the Chinese population. PMID: 23303631
43. Proteolytic processing of the caspase-9 zymogen is required for apoptosome-mediated activation of caspase-9. PMID: 23572523
44. Polymorphism in Caspase 9 (-1263 A>G) was observed to be associated with susceptibility to papillary thyroid carcinoma (PTC). PMID: 22120515
45. Induction of caspase-9b expression is due to activation of hnRNP L via phosphorylation to compete/inhibit hnRNP U association with exon 3 of Casp9 mRNA. PMID: 23396972
46. These results clearly indicated that olive oil phenolic extract and gallic acid were able to inhibit the caspase 9-dependent apoptosis pathway in HeLa cells. PMID: 22086301
47. The overexpression of c-Jun, p73, and Casp-9 in thymic epithelial tumors is closely related to the pathogenesis and biological behavior of the neoplasms. PMID: 22974165
48. Data suggest that CD95L-triggered endogenous ceramide increase in Jurkat leukemia T cells is likely involved in the pro-apoptotic mitochondrial pathway leading to caspase-9 activation. PMID: 22306364
49. Caspase-9 is the most important regulator in DLD-1, HCT-116, and HeLa cells. PMID: 23038270
50. CASP9 promoter polymorphisms rs4645978 and rs4645981 are associated with breast cancer susceptibility; CASP9 transcriptional regulation is a significant factor during breast cancer development. PMID: 22981751

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HGNC: 1511

OMIM: 602234

KEGG: hsa:842

STRING: 9606.ENSP00000330237

UniGene: Hs.329502