Cleaved-ITIH2 (D702) Antibody
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Product Specs
Buffer
The antibody is provided as a liquid solution in phosphate-buffered saline (PBS) containing 50% glycerol, 0.5% bovine serum albumin (BSA) and 0.02% sodium azide.
Form
Liquid
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your order. Delivery times may vary depending on the purchasing method or location. Please consult your local distributors for specific delivery time information.
Synonyms
AI747202 antibody; H2P antibody; IGHEP2 antibody; Inter alpha (globulin) inhibitor H2 antibody; Inter alpha globulin inhibitor H2 polypeptide antibody; Inter alpha trypsin inhibitor complex component II antibody; Inter alpha trypsin inhibitor heavy chain H2 antibody; Inter-alpha-inhibitor heavy chain 2 antibody; Inter-alpha-trypsin inhibitor complex component II antibody; Inter-alpha-trypsin inhibitor heavy chain H2 antibody; Intin2 antibody; ITI HC2 antibody; ITI heavy chain H2 antibody; ITI-HC2 antibody; Itih 2 antibody; Itih2 antibody; ITIH2_HUMAN antibody; OTTHUMP00000019058 antibody; OTTHUMP00000019059 antibody; OTTMUSP00000012019 antibody; RP23 119N4.3 antibody; Serum derived hyaluronan associated protein antibody; Serum-derived hyaluronan-associated protein antibody; SHAP antibody
Target Names
ITIH2
Uniprot No.
Target Background
Function
Cleaved-ITIH2 (D702) antibody is a monoclonal antibody that recognizes the cleaved form of inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2) protein. ITIH2 is a plasma protein that plays a crucial role in various biological processes, including inflammation and tissue repair. It may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix proteins, including those on cell surfaces in tissues. This interaction helps regulate the localization, synthesis, and degradation of hyaluronan, which are essential for cells undergoing various biological processes.
Gene References Into Functions
- Cleaved-ITIH2 forms a complex with hyaluronan, creating a functional molecule involved in inflammation. PMID: 20297716
- TSG-6 (tumor necrosis factor-stimulated gene-6) acts as a cofactor and catalyst in the production of IalphaI heavy chain x hyaluronan complexes. PMID: 15840581
- Leukocytes that infiltrate the synovium exhibit strong positivity for hyaluronic acid, SHAP (serum-derived hyaluronan-associated protein), and CD44 on their surfaces, suggesting a role for the adhesion-enhancing effect of SHAP in inflammation. PMID: 16702221
- Elevated levels of the SHAP-HA complex in sera are potential predictive markers for cervical ripening in premature labor. PMID: 18382897
- Serum-derived hyaluronan-associated protein-hyaluronan complex has a role in the progression of ovarian cancer. PMID: 18425383
Database Links
Protein Families
ITIH family
Subcellular Location
Secreted.
Tissue Specificity
Plasma.
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