chc-1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
chc-1 antibody; T20G5.1Probable clathrin heavy chain 1 antibody
Target Names
chc-1
Uniprot No.
Target Background
Function
Clathrin is a ubiquitous protein that forms the polyhedral coat of coated pits and vesicles. It is essential for clathrin-mediated endocytosis, a fundamental cellular process that involves the uptake of molecules from the extracellular environment. In oocytes, clathrin may play a role in the endocytosis of yolk proteins during oogenesis.
Gene References Into Functions
- In *Caenorhabditis elegans* embryos, the clathrin heavy chain CHC-1 plays a crucial role in regulating pulling forces on centrosomes during interphase and on spindle poles during mitosis. PMID: 24961801
- Studies have shown that the inactivation of *epn-1* or *chc-1* genes disrupts engulfment by impairing actin polymerization. CHC-1 is concentrated on extending pseudopods, alongside EPN-1, in an EPN-1-dependent manner. PMID: 23861060
- Research suggests that a high level of CHC activity is essential for receptor-mediated endocytosis in non-neuronal cells, but it is largely dispensable for the maintenance of synaptic vesicle pools. PMID: 19151157
Database Links
Protein Families
Clathrin heavy chain family
Subcellular Location
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
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