clh-3 Antibody

CLH-3 is a voltage-gated chloride channel in *Caenorhabditis elegans*. It exhibits unique characteristics: insensitivity to depolarizing conditioning voltages, activation at low voltages, independence from chloride levels, and mild sensitivity to low pH. The cytoplasmic C-terminus plays a crucial role in its gating properties. CLH-3 plays a role in egg laying by modulating the excitability of hermaphrodite-specific neurons (HSN) and the ovulatory contractions of gap-junction-coupled gonadal sheath cells. Its activation may prevent the formation of tubular excretory canals. CLH-3 is activated during oocyte meiotic maturation, membrane hyperpolarization, and cell swelling. Notably, it is inhibited by Zn(2+) and, to a lesser extent, by Cd(2+). Another voltage-gated chloride channel, also sensitive to depolarizing conditioning voltages, requires stronger voltages for activation, and its activation is slower. This channel is inhibited by low concentrations of chloride and activated by low pH. Similarly, the cytoplasmic C-terminus influences its channel gating properties.