clhm-1 Antibody
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Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
clhm-1 antibody; C44B7.4Calcium homeostasis modulator protein antibody
Target Names
clhm-1
Uniprot No.
Target Background
Function
CLHM-1 is a pore-forming subunit of a voltage-gated ion channel. It exhibits permeability to monovalent cations, divalent cations, and anions, displaying a selectivity pattern of Ca(2+) > Mg(2+) > Na(+) = K(+) > Cl(-). This protein functions as both a voltage-gated and calcium-activated ion channel. CLHM-1 is essential for normal locomotion.
Gene References Into Functions
- Mutations in ceCLHM-1, specifically at valine 9 and glutamine 13, resulted in alterations in half-maximal activation and voltage dependence, respectively. In the absence of Ca(2+) (0 Ca(2+) In) and presence of 2 mM Ca(2+) in the external environment (2 mM Ca(2+)o), the ceCLHM-1 NH2-terminal deletion and point mutant channels exhibited complete closure at hyperpolarized voltages. Notably, their apparent affinity for Ca(2+)o remained indistinguishable from that of the wild-type ceCLHM-1. PMID: 28515089
- Research findings indicate that CLHM-1 is a functionally conserved ion channel that plays a crucial, albeit potentially toxic, role in the function of excitable cells. PMID: 23884934
Database Links
KEGG: cel:CELE_C44B7.4
UniGene: Cel.15677
Protein Families
CALHM family
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Tissue Specificity
Expressed in head and body wall muscles, IL2, ASG, ASI, ASJ, PHA and PHB sensory neurons, and spermatheca.
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