clk-2 Antibody
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In Stock 
Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
clk-2 antibody; rad-5 antibody; C07H6.6Telomere length regulation protein clk-2 antibody; Clock abnormal protein 2 antibody
Target Names
clk-2
Uniprot No.
Target Background
Function
CLK-2 is a DNA damage checkpoint protein essential for DNA damage-induced cell cycle arrest and apoptosis. This crucial role contributes to genome stability. CLK-2 also acts as a regulator of telomere length.
Gene References Into Functions
- In C. elegans germ cells, the CLK-2 checkpoint protein suppresses mutation frequency by ensuring accurate repair of spontaneous DNA damage. PMID: 16951081
- Persistent repair intermediates or single-stranded DNA arising during uracil misincorporation repair are tolerated in C. elegans when the CLK-2 checkpoint is absent. PMID: 16964178
- CLK-2 mutants exhibit genomic instability and a delay in embryonic cell cycle timing. PMID: 19360121
Database Links
Protein Families
TEL2 family
Subcellular Location
Nucleus. Chromosome, telomere.
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