CLSTN1 Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze/thaw cycles.
Lead Time
Typically, we can ship products within 1-3 business days of receiving your order. Delivery times may vary depending on the purchase method or location. For specific delivery information, please consult your local distributors.
Synonyms
Alc alpha antibody; Alc-alpha antibody; Alcadein alpha 1 antibody; Alcadein alpha antibody; Alcadein-alpha antibody; alcalpha1 antibody; alcalpha2 antibody; Alzheimer related cadherin like protein antibody; Alzheimer-related cadherin-like protein antibody; C-terminal fragment 1-alpha antibody; Cadherin related family member 12 antibody; Calsyntenin 1 antibody; Calsyntenin1 antibody; CDHR12 antibody; CLSTN 1 antibody; Clstn1 antibody; CS1 antibody; CSTN1 antibody; CSTN1_HUMAN antibody; CTF1-alpha antibody; FLJ32258 antibody; KIAA0911 antibody; Non classical cadherin XB31alpha antibody; Non classical cadherin XB31alpha1 antibody; Non-classical cadherin XB31alpha antibody; PIK3CD antibody; SAlc-alpha antibody; XB31alpha antibody
Target Names
CLSTN1
Uniprot No.
Target Background
Function
Calsyntenin-1 (CLSTN1) promotes KLC1 association with vesicles and acts as a cargo in axonal anterograde transport. Its complex formation with APBA2 and APP stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion by delaying intracellular APP maturation. When complexed with APBA2 and C99, a C-terminal APP fragment, CLSTN1 inhibits C99 interaction with PSEN1 and consequently APP C99 cleavage by gamma-secretase, potentially through stabilizing the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), likely by competing with AICD for APBB1 binding. CLSTN1 might also modulate calcium-mediated postsynaptic signals.
Gene References Into Functions
- Studies suggest that APP partially compensates for defective Alcalpha in anterograde transport by serving as an alternative cargo receptor for kinesin-1. PMID: 29093024
- Calsyntenin-1 contributes to the early stages of hepatitis C virus replication and the formation of the replication complex. PMID: 27221318
- Elevated plasma levels of p3-Alcalpha35, a major fragment of alcalpha1, may indicate an endophenotype in Alzheimer's disease patients with progressive cognitive impairment. PMID: 24305499
- Increased plasma levels of p3-alcadein (alc) alpha, observed in the early stages of cognitive impairment, suggest that alc metabolites are valuable plasma biomarkers of Alzheimer's disease. PMID: 22571980
- Research indicates that calsyntenin-1 is reduced in Alzheimer's disease brains, and the extent of this reduction correlates with increased amyloid-beta. PMID: 22434822
- CLSTN1 is identified as a target gene of the BACH1 transcription factor based on ChIP-seq analysis in HEK 293 cells. PMID: 21555518
- Phosphorylation of KLC1 at serine 460 regulates the binding and trafficking of calsyntenin-1. PMID: 21385839
- Alcadein and amyloid beta-protein precursor regulate FE65-dependent gene transactivation [alcalpha1, alcbeta, alcgamma]. PMID: 15037614
Database Links
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane. Cell projection, neuron projection. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein. Nucleus.
Tissue Specificity
Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level).
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