CM2 Antibody

Introduction to CM2 Antibody

The term "CM2 Antibody" refers to distinct biological entities depending on context, primarily encompassing (1) antibodies targeting the Muscarinic Acetylcholine Receptor 2 (CHRM2) and (2) antibodies against viral CM2 proteins, such as those from human cytomegalovirus (HCMV) or influenza C virus. These antibodies differ in target specificity, structural features, and applications, as detailed below.

Muscarinic Acetylcholine Receptor 2 (CHRM2) Antibody

• Target: CHRM2, a G protein-coupled receptor (GPCR) in the autonomic nervous system and cardiovascular system .

• Antibody Type: Monoclonal (e.g., clone 31-1D1) and polyclonal antibodies .

• Structure:

  • Immunogen: Native full-length pig CHRM2 or recombinant human CHRM2 fragments (e.g., amino acids 208–388) .

  • Isotype: IgG1 for monoclonal antibodies .

Viral CM2 Antibodies

• HCMV CM2 Antibody: Targets nonstructural HCMV proteins (UL44 and UL57) .

• Influenza C CM2 Antibody: Binds to the CM2 ion channel protein, generated from a 374-amino-acid precursor (P42) .

CHRM2 Antibody Applications

• Mechanism: CHRM2 mediates acetylcholine signaling, inhibiting adenylate cyclase and modulating potassium channels .

• Research Use:

  • Detects CHRM2 expression in Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) .

  • Used to study CHRM2’s role in cardiac hypertrophy and endoplasmic reticulum stress .

Viral CM2 Antibody Significance

• HCMV CM2: IgM antibodies against CM2/p52 serve as biomarkers for chronic fatigue syndrome (CFS) .

• Influenza C CM2: Antibodies target the viral ion channel critical for uncoating and replication .

Research Applications

CHRM2 in Disease

• Cardiovascular Regulation: CHRM2 modulates heart rate and contractility; antibodies aid in studying its role in arrhythmias .

HCMV CM2 in Chronic Fatigue Syndrome

• Diagnostic Utility: IgM antibodies against HCMV CM2/p52 are specific to a CFS subset, suggesting persistent viral antigen processing .

Comparative Analysis of CM2 Antibody Types

Future Directions

• CHRM2 Antibodies: Development of therapeutic antibodies for heart failure or neurodegenerative diseases .

• Viral CM2 Antibodies: Broader diagnostic panels for HCMV-associated CFS and antiviral therapies targeting influenza C CM2 .