cmk-1 Antibody

CMK-1 is a calcium/calmodulin-dependent protein kinase that plays a crucial role in the calcium-triggered CaMKK-CaMK1 signaling cascade. This cascade ultimately leads to transcriptional activation, at least partially through the phosphorylation of crh-1. CMK-1 regulates gene expression, sensory morphology, and functionality of the AFD thermosensory neurons. It is involved in long-term adaptation of AFD neurons to temperatures exceeding the initial acclimatized cultivation temperature. In FLP thermal nociceptors, CMK-1 modulates the responsiveness to noxious heat and controls neuropeptide release from FLP neurons in response to temperature elevations. CMK-1 also regulates the dauer decision, influencing the larval decision to enter the dauer developmental stage (a stress-resistant and long-lived stage), based on the feeding state, primarily within the AWC sensory neurons. It acts non-cell-autonomously in AWC neurons to regulate expression of the daf-28 insulin-like peptide and cell-autonomously in ASI sensory neurons to regulate the expression of the growth promoting daf-7 in a food-regulated manner. CMK-1 plays a significant role in the memory-based thermal response of individual AFD neuron cells. It is involved in chemotaxis response in AWC neurons to attractant 2-heptanone, a volatile organic compound emitted by the nematode pathogenic bacterium B.nematocida B16. CMK-1 plays a role in salt avoidance learning, a type of aversive gustatory associated learning, via regulation of crh-1 signaling and the promotion of long-term memory formation. Finally, CMK-1 represses transcription of the glutamate receptor glr-1 in the nucleus both basally and in response to changes in synaptic activity.