tax-4 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
tax-4 antibody; ZC84.2Cyclic nucleotide-gated cation channel antibody; Abnormal chemotaxis protein 4 antibody
Target Names
tax-4
Uniprot No.
Target Background
Function
TAX-4 plays a crucial role in various sensory functions in *Caenorhabditis elegans*. It is essential for normal thermosensation and chemosensation, contributing to sensory behaviors. Specifically, TAX-4 functions downstream of receptor-type guanylate cyclases: GCY-9 for CO2-mediated responses in BAG neurons and GCY-14 for alkaline pH-mediated responses in ASEL neurons. TAX-4 also participates in the development and maintenance of ASJ sensory neuron axons, regulating dauer formation. Furthermore, it mediates calcium influx into ASJ sensory neurons upon NO stimulation, promoting behavioral avoidance of NO-producing organisms like *P. aeruginosa*. TAX-4 regulates behavioral responses to *P. aeruginosa* in ASI and ASJ neurons by upregulating the transcription of DAF-7, a TGF-β family member. In AWB and AWC sensory neurons, TAX-4 facilitates the recognition of food odors, enabling the detection of preferred food sources. In AWC neurons, it promotes the expression of SRSX-3, a GPCR family member.
Gene References Into Functions
- The cryo-electron microscopy structure of TAX-4 provides insights into the mechanisms of ion permeation, gating, and channelopathy in cyclic-nucleotide-gated channels and the modulation of related channels by cyclic nucleotides. PMID: 28099415
- Mutants lacking TAX-4 exhibit abnormal thermal responses, indicating their involvement in warm avoidance. PMID: 12819265
- Wild-type worms display an L1 (first larval stage) surface epitope at later larval stages when grown on an extract of spent culture medium. This phenomenon is abolished in chemotaxis-defective TAX-4 mutants. PMID: 16879619
Database Links
Protein Families
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
Subcellular Location
Membrane; Multi-pass membrane protein.
Tissue Specificity
Expressed at the sensory endings of thermosensory, gustatory, and olfactory neurons.
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