CNOT2 Antibody
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In Stock 
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid freeze / thaw cycles.
Lead Time
Typically, we can ship the products within 1-3 business days of receiving your order. Delivery times may vary depending on the purchasing method or location. Please contact your local distributor for specific delivery details.
Synonyms
CCR4 associated factor 2 antibody; CCR4 NOT transcription complex subunit 2 antibody; CCR4-associated factor 2 antibody; CCR4-NOT transcription complex subunit 2 antibody; CDC36 antibody; CNOT2 antibody; CNOT2_HUMAN antibody; HSPC131 antibody; MSTP046 antibody; Negative regulator of transcription 2 antibody; NOT2 (negative regulator of transcription 2 yeast) homolog antibody; NOT2 antibody; NOT2H antibody
Target Names
CNOT2
Uniprot No.
Target Background
Function
CNOT2 is a component of the CCR4-NOT complex, a key cellular mRNA deadenylase involved in various cellular processes. These processes include bulk mRNA degradation, miRNA-mediated repression, translational repression during initiation, and general transcription regulation. Its impact on mRNA expression contributes to the complex's diverse functions. CNOT2 is crucial for the CCR4-NOT complex's structural integrity and can repress transcription. It potentially links the complex to transcriptional regulation, possibly through the N-Cor repressor complex containing HDAC3, NCOR1, and NCOR2. CNOT2 plays a role in maintaining embryonic stem (ES) cell identity.
Gene References Into Functions
- CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells. PMID: 29024811
- ERG is recruited to mRNAs through interaction with the RNA-binding protein RBPMS, promoting mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex. PMID: 27273514
- The CNOT2-CNOT3 heterodimer exhibits a stable and tightly anchored association with the surface of CNOT1. This interaction involves an unexpected intertwined arrangement of peptide regions lacking defined secondary structure. PMID: 24121232
- Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry, conserved in both mouse and human ESCs. PMID: 22367759
- Human CNOT2 is essential for maintaining the deadenylase activity and structural integrity of the CCR4-NOT complex, thus affecting cell viability. PMID: 21299754
- This study demonstrates that the SMRT/NCoR-HDAC3 complex serves as a cofactor in CNOT2-mediated repression, suggesting that transcriptional regulation by the Ccr4-Not complex involves regulation of chromatin modification. PMID: 16712523
- The primary repression function of CNOT2 is localized within a specialized protein motif, the Not-Box. PMID: 14707134
- These findings suggest that CDK11 may contribute to apoptosis by regulating the activity of NOT2, independent of its kinase activity. PMID: 16039607
Database Links
Protein Families
CNOT2/3/5 family
Subcellular Location
Cytoplasm. Nucleus.
Tissue Specificity
Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.
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