COL4 Antibody

Monoclonal Antibodies

• Clone 1042 (Thermo Fisher):

  • Host: Mouse.

  • Applications: Immunoprecipitation, Western blot, IHC (FFPE/frozen) .

  • Specificity: Human collagen IV; ≤5 µg/mL working concentration .

• Clone RBT-COL4A1 (Bio SB):

  • Host: Rabbit.

  • Applications: Diagnosing basement membrane loss in carcinomas, classifying soft tissue tumors .

Polyclonal Antibodies

• ABIN5596835 (Antibodies-Online):

  • Host: Rabbit.

  • Cross-Reactivity: Negligible with collagen types I, II, III, V, VI .

  • Applications: ELISA, IHC, IP, WB .

Applications in Research and Diagnostics

Research Findings

• HTLV-1 Pathogenesis: COL4A1/A2 upregulation in HTLV-1-infected T-cells enhances viral biofilm (VB) formation, promoting cell-to-cell transmission .

• Disease Correlation: Elevated COL4A2 mRNA in slowly progressing HAM/TSP patients suggests a role in neuroinflammatory modulation .

• Tumor Specificity: COL4 overexpression is absent in Burkitt lymphoma and Hodgkin lymphoma cell lines, indicating HTLV-1-specific oncogenic mechanisms .