cope-1 Antibody
Description
Introduction to COPE-1 Antibody
COPE-1 Antibody specifically binds to the COPE protein (36 kDa), a subunit of the coatomer protein complex I (COPI) that facilitates retrograde transport between the Golgi apparatus and endoplasmic reticulum . This antibody has been studied for its potential role in predicting atherosclerosis-related cardiovascular and cerebrovascular events in patients with obstructive sleep apnea (OSA) .
Research Findings in Cardiovascular Risk Prediction
A 2017 study involving patients with OSA linked elevated COPE-Ab levels to atherosclerosis-related events :
Broader Implications and Databases
Product Specs
Components: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Target Background
COPI (Coatomer protein complex I) is a cytosolic protein complex that recognizes dilysine motifs and dynamically associates with non-clathrin-coated vesicles in the Golgi apparatus. These vesicles are crucial for the transport of biosynthetic proteins from the endoplasmic reticulum (ER), through the Golgi apparatus, to the trans-Golgi network (TGN). COPI is essential for vesicle budding from Golgi membranes and plays a vital role in the retrograde transport of dilysine-tagged proteins from the Golgi back to the ER.
