clk-1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
clk-1 antibody; ZC395.2 antibody; 5-demethoxyubiquinone hydroxylase antibody; mitochondrial antibody; DMQ hydroxylase antibody; EC 1.14.13.- antibody; Clock abnormal protein 1 antibody; Protein clk-1 antibody; Ubiquinone biosynthesis monooxygenase COQ7 antibody
Target Names
clk-1
Uniprot No.
Target Background
Function
CLK-1 antibody is a crucial enzyme involved in ubiquinone biosynthesis. It catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2), a key step in the production of ubiquinone. Beyond its catalytic role, CLK-1 also plays a structural role within the COQ enzyme complex, providing stability to other COQ polypeptides. Notably, CLK-1 has been implicated in lifespan determination, independent of its role in ubiquinone biosynthesis.
Gene References Into Functions
- Loss of ubiquinone biosynthesis is the underlying cause for all phenotypes observed in CLK-1 deficient organisms, including behavioral changes, altered expression of mitochondrial quality control genes, and lifespan alterations. PMID: 28404998
- CLK-1, when localized in the nucleus, mediates a retrograde signaling pathway that is conserved across species, from Caenorhabditis elegans to humans. This pathway is responsive to mitochondrial reactive oxygen species, effectively acting as a sensor for oxidative metabolism. PMID: 25961505
- Analysis of clk-1 mutant mitochondria reveals no detectable intrinsic electron transport chain (ETC) defects. The data indicate that DMQ(9) specifically inhibits electron transfer from complex I to ubiquinone. PMID: 21745495
- CLK-1 from Caenorhabditis elegans successfully complements the ubiF mutation in Escherichia coli, demonstrating its functional conservation. PMID: 12753928
- Caenorhabditis elegans clk-1 mutants exhibit sensitivity to the length of the ubiquinone side-chain. PMID: 12893826
- In maternally rescued animals, the effects of clk-1 mutations on adult lifespan are decoupled from their effects on development and reproduction. PMID: 14517217
- Differences in fertility observed in clk-1 mutant nematodes fed various Q isoforms may be attributed to changes in Q localization, altered recognition by Q-binding proteins, and/or potential defects in mitochondrial function arising from the mutant CLK-1 polypeptide itself. PMID: 14530273
- Suppressors of the missense mutation of clk-1 have been identified, each exhibiting suppression of a distinct subset of phenotypes. PMID: 16648490
- The observed action of clioquinol on several age-dependent neurodegenerative diseases with distinct etiologies may be attributed to a slowing down of the aging process through its effect on CLK-1. PMID: 18927074
Database Links
Protein Families
COQ7 family
Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
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