CPNE1 Antibody, Biotin conjugated
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship your order within 1-3 business days of receiving it. The delivery timeframe may vary depending on the shipping method and location. Please consult your local distributor for specific delivery details.
Synonyms
Copine 1 antibody; Copine I antibody; Copine-1 antibody; Copine1 antibody; CopineI antibody; COPN 1 antibody; COPN1 antibody; CPN 1 antibody; CPN1 antibody; CPNE 1 antibody; CPNE1 antibody; CPNE1_HUMAN antibody; MGC1142 antibody
Target Names
CPNE1
Uniprot No.
Target Background
Function
CPNE1 (Copine I) is a calcium-dependent phospholipid-binding protein involved in calcium-mediated intracellular processes. It plays a crucial role in the TNF-alpha receptor signaling pathway, operating in a calcium-dependent manner. CPNE1 exhibits calcium-dependent phospholipid binding characteristics and is implicated in neuronal progenitor cell differentiation, inducing neurite outgrowth through an AKT-dependent signaling cascade that is independent of calcium. This protein may recruit target proteins to the cell membrane in a calcium-dependent fashion and may function in membrane trafficking. Additionally, CPNE1 is involved in TNF-alpha-induced NF-kappa-B transcriptional repression by triggering endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. It also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB, and REL.
Gene References Into Functions
- Research has shown that CPNE1 is highly expressed in osteosarcoma (OS) tissues and cell lines. Knockdown of CPNE1 significantly inhibited cell proliferation, colony formation, invasion, and metastasis in OS cell lines. PMID: 29207139
- Overexpression of CPNE1 has been shown to upregulate TRAF2 expression in prostate cancer DU-145 cells as determined by Western blotting and immunofluorescence assays. PMID: 29151113
- Studies suggest that JAB1 activates the neuronal differentiation ability of CPNE1 through the binding of the C2A domain in CPNE1 with the MPN domain in JAB1. PMID: 29448099
- Copine I regulates tumor necrosis factor-alpha receptor signaling pathways. PMID: 14674885
- Copine1 is upregulated in plasma membranes of TM cells in individuals with primary open-angle glaucoma. PMID: 18523666
- CPNE1 shares a promoter and 5'UTR exons with RBM12. This genomic structure is conserved among multiple species. PMID: 18831769
Database Links
Protein Families
Copine family
Subcellular Location
Nucleus. Cytoplasm. Cell membrane.
Tissue Specificity
Expressed in neutrophils (at protein level). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from bone marrow and peripheral blood.
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