CREB3L4 Antibody
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Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Stored at -20°C. Avoid freeze-thaw cycles.
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your order. Delivery time may vary depending on the purchasing method or location. For specific delivery times, please consult your local distributors.
Synonyms
1700012K17Rik antibody; AIbZIP antibody; Androgen induced basic leucine zipper antibody; Androgen induced basic leucine zipper protein antibody; Androgen-induced basic leucine zipper protein antibody; ATCE1 antibody; Attaching to CRE like 1 antibody; Attaching to CRE-like 1 antibody; cAMP responsive element binding protein 1 antibody; cAMP responsive element binding protein 3 like 4 antibody; cAMP responsive element binding protein 4 antibody; cAMP responsive element-binding protein 3 like protein 4 antibody; cAMP-responsive element-binding protein 3-like protein 4 antibody; cAMP-responsive element-binding protein 4 antibody; CR3L4_HUMAN antibody; CREB 4 antibody; CREB-4 antibody; CREB3 antibody; CREB3L4 antibody; CREB4 antibody; Cyclic AMP responsive element binding protein 3 like protein 4 antibody; Cyclic AMP responsive element binding protein 4 antibody; Cyclic AMP-responsive element-binding protein 4 antibody; hJAL antibody; JAL antibody; mJAL antibody; Processed cyclic AMP-responsive element-binding protein 3-like protein 4 antibody; Tisp40 antibody; Tisp40alpha antibody; Tisp40beta antibody; Transcript induced in spermiogenesis protein 40 antibody
Target Names
Uniprot No.
Target Background
Function
CREB3L4 is a transcriptional activator that may play a role in the unfolded protein response. It binds to the UPR element (UPRE) but not to the CRE element. CREB3L4 preferentially binds to DNA with the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and exhibits transcriptional activation activity from UPRE. It also binds to the NF-kappa-B site and possesses transcriptional activation activity from NF-kappa-B-containing regulatory elements.
Gene References Into Functions
- CREB3L4 expression is regulated by an androgen-receptor -IRE1alpha axis, but is also directly regulated by androgen-receptor binding to androgen response elements. PMID: 28338058
- AIbZIP, induced by the androgen receptor axis, plays a crucial role in the p21 dependent proliferation of androgen-sensitive prostate cancer cells. PMID: 27853318
- AIbZIP is a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors. Its expression is up-regulated by androgens in LNCaP human prostate cancer cells. PMID: 11830526
- A novel human CREB gene (CREB4) was identified, spanning 1592 bp and encoding a protein of 395 amino acid residues. PMID: 12111373
- S1P cleavage of CREB4 may be suppressed by a determinant in the C-terminal region. PMID: 16236796
- In LNCaP cell lines expressing the processed form of AIbZIP, downstream targets include genes involved in protein processing, transcriptional regulation, small molecule transport, signal transduction, metabolism, and cell homeostasis. PMID: 17712038
Database Links
Protein Families
BZIP family, ATF subfamily
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Tissue Specificity
According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than
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