che-10 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
che-10 antibody; dyf-14 antibody; F35D11.11Rootletin antibody; Abnormal dye filling protein 14 antibody; Chemotaxis abnormal protein 10 antibody
Target Names
che-10
Uniprot No.
Target Background
Function
CHE-10 antibody targets Girdin, a major structural component of the ciliary rootlet. The ciliary rootlet is a cytoskeletal-like structure found in ciliated cells. It originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Girdin is essential for cilia integrity and function in sensory neurons. It plays a crucial role in maintaining cilia integrity by modulating the assembly and transport of intraflagellar proteins along the ciliary axoneme. Furthermore, Girdin is required for normal mating behavior and proper responses to environmental and chemical stimuli.
Gene References Into Functions
- In *C. elegans*, Girdin also regulates the localization of the apical junction component AJM-1, suggesting that Girdin may position basal bodies through rootletin- and AJM-1-dependent anchoring to the cytoskeleton and plasma membrane, respectively. These findings highlight a conserved role for Girdin in basal body positioning and ciliogenesis. PMID: 27623382
Database Links
Protein Families
Rootletin family
Subcellular Location
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme.
Tissue Specificity
Expressed in head ciliated neurons.
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