CRRSP21 Antibody

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Description

CR2/CD21 Antibody

The search results extensively describe CR2 (CD21), a complement receptor critical for B-cell activation and immune response modulation . Notable features include:

PropertyDetails
StructureType I transmembrane glycoprotein with extracellular SCR domains
FunctionBinds complement C3d, enhances antigen presentation, regulates BCR signaling
Clinical RelevanceBiomarker for mature B cells; therapeutic target in autoimmune diseases
Species ReactivityHuman-specific antibodies (e.g., CR2/3124R clone) validated for IHC, WB, and flow cytometry

SARS-CoV-2 Antibody Research

Recent studies highlight advancements in antibody therapies targeting viral proteins (e.g., spike/nucleocapsid), with comparisons of neutralizing efficacy against variants like Omicron BA.4/5 . For example:

  • Bamlanivimab/Etesevimab showed lower hospitalization rates (12.7%) vs. Casirivimab/Imdevimab (28.4%) in high-risk patients .

  • Omicron subvariants evade antibodies via mutations (e.g., L452M/Q, F486V) that reduce neutralization by 4.2-fold compared to earlier strains .

Recommendations for Clarification

To resolve the ambiguity around "CRRSP21 Antibody":

  1. Verify nomenclature: Cross-check with institutional databases or proprietary catalogs for potential naming variations (e.g., CRISPR-associated proteins, CR1/CR2 isoforms).

  2. Explore CR2-related pathways: Given the prominence of CD21/CR2 in B-cell biology , investigate whether "CRRSP21" relates to CR2 splice variants or signaling partners like CD19/CD81 .

  3. Consult updates: Monitor repositories like ClinicalTrials.gov or preprint servers (e.g., medRxiv) for emerging studies using this term .

Product Specs

Buffer
Preservative: 0.03% Proclin 300
Composition: 50% Glycerol, 0.01M Phosphate Buffered Saline (PBS), pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
CRRSP21 antibody; At3g21937 antibody; MZN24.7Putative cysteine-rich repeat secretory protein 21 antibody
Target Names
CRRSP21
Uniprot No.

Target Background

Protein Families
Cysteine-rich repeat secretory protein family
Subcellular Location
Secreted.

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