CSDC2 Human

Cold Shock Domain Containing C2 Human Recombinant
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Cat. No.
BT2816
Source
Escherichia Coli.
Synonyms
Cold shock domain-containing protein C2, RNA-binding protein PIPPin, PIPPIN, DJ347H13.2.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

Functional Roles

CSDC2 regulates RNA processing and cellular pathways through interactions with:

  • Histone mRNAs: Binds 3'-UTR of histone H1 and H3.3 mRNAs to control synthesis during brain development .

  • Protein Partners: Interacts with PPP2R1A (protein phosphatase regulator), DICER1 (RNA interference), and RBKS (ribose phosphorylation) .

  • Stress Responses: Linked to adaptation to low temperature, nutrient stress, and stationary phase .

Role in Hair Follicle Development (2024)

  • Study: Int. J. Mol. Sci. (2024) demonstrated Csdc2 promotes secondary hair follicle growth in cashmere goats .

  • Mechanism:

    • Binds intron 6 of Robo2 (roundabout guidance receptor) to upregulate its expression .

    • Knockdown reduced DPC (dermal papilla cell) proliferation by 40% (p < 0.001) .

  • Methods: ChIP-seq, RNA-seq, and dual luciferase assays confirmed regulatory relationships .

Cardio-Metabolic Stress (2023)

  • Study: Circulation Research (2023) linked CSDC2 to heart failure and metabolic dysfunction .

  • Findings:

    • CSDC2-KO mice showed 20% higher weight gain on high-fat diets (p = 0.04) and insulin resistance .

    • Post-myocardial infarction mortality doubled (70% vs. 40% in wildtype) .

Decidualization in Pregnancy (2018)

  • Study: siRNA-mediated CSDC2 suppression disrupted uterine decidualization in mice .

  • Impact: Abnormal antimesometrial growth and impaired mesometrial development .

Protein Interaction Network

CSDC2 associates with proteins involved in RNA processing and metabolism :

PartnerFunctionInteraction Score
PPP2R1AProtein phosphatase regulation0.721
DICER1miRNA processing0.642
RBKSRibose phosphorylation0.678
MGAT3Glycoprotein biosynthesis0.565

Clinical and Therapeutic Implications

  • Hair Disorders: Potential target for alopecia or hair growth therapies .

  • Cardiovascular Disease: CSDC2 loss exacerbates heart failure post-infarction .

  • Reproductive Health: Critical for proper decidualization in early pregnancy .

Future Directions

Research should explore:

  • Tissue-specific CSDC2 isoforms.

  • Pharmacological modulation in metabolic or cardiac diseases.

  • Role in cancer (via DICER1/PPP2R1A pathways) .

Product Specs

Introduction
CSDC2, also known as Cold shock domain-containing protein C2, is an RNA-binding protein with a specific affinity for the 3'-UTR ends of histone H1 and H3 mRNAs, encompassing the polyadenylation signal. Belonging to the evolutionarily conserved CSDP family (cold shock domain containing proteins), CSDC2 is found across various organisms, from bacteria to plants and animals. CSDPs play a crucial role in a range of cellular processes, including cold adaptation, growth regulation, response to nutrient stress, and stationary phase entry. Notably, CSDC2 plays a central role in the developing brain by negatively regulating the synthesis of histone variants.
Description
Recombinantly produced in E.coli, CSDC2 Human Recombinant is a single, non-glycosylated polypeptide chain consisting of 176 amino acids (1-153). With a molecular weight of 19.2kDa, this protein features a 23 amino acid His-tag fused at its N-terminus.
Physical Appearance
A clear, colorless solution, sterilized by filtration.
Formulation
The CSDC2 solution is prepared at a concentration of 0.5mg/ml in a buffer consisting of 20mM Tris-HCl (pH 8.0), 10% glycerol, and 0.1M NaCl.
Stability
For short-term storage (2-4 weeks), the CSDC2 vial should be kept at 4°C. For longer-term storage, it's recommended to store the protein frozen at -20°C. Adding a carrier protein like HSA or BSA (0.1%) is advised for extended storage. To maintain protein integrity, avoid repeated cycles of freezing and thawing.
Purity
High purity exceeding 90.0% as determined by SDS-PAGE analysis.
Synonyms
Cold shock domain-containing protein C2, RNA-binding protein PIPPin, PIPPIN, DJ347H13.2.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMTSESTS PPVVPPLHSP KSPVWPTFPF HREGSRVWER GGVPPRDLPS PLPTKRTRTY SATARASAGP VFKGVCKQFS RSQGHGFITP ENGSEDIFVH VSDIEGEYVP VEGDEVTYKM CPIPPKNQKF QAVEVVLTQL APHTPHETWS GQVVGS.

Product Science Overview

Introduction

Cold Shock Domain Containing C2 (CSDC2) is a protein encoded by the CSDC2 gene in humans. This protein is part of the cold shock domain (CSD) family, which is characterized by the presence of one or more cold shock domains. These domains are known for their nucleic acid binding properties, which enable them to participate in various cellular processes, including the regulation of transcription, translation, and splicing .

Gene and Protein Structure

The CSDC2 gene is located on chromosome 22 and is a protein-coding gene. The protein encoded by this gene contains a cold shock domain, which is crucial for its function in nucleic acid binding. The CSDC2 protein is also known by other names, such as RNA-Binding Protein PIPPin .

Biological Functions

CSDC2 is an RNA-binding factor that specifically binds to the very 3’-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. This binding activity suggests that CSDC2 might play a central role in the negative regulation of histone variant synthesis in the developing brain . Additionally, CSDC2 is predicted to be involved in the regulation of mRNA stability and is active in both the nucleus and cytoplasm .

Evolutionary Significance

Cold shock proteins, including CSDC2, are among the most evolutionarily conserved proteins. They are found in almost all organisms, from bacteria to humans, except yeast. This conservation highlights their fundamental role in cellular processes .

Clinical Relevance

The expression patterns of cold shock proteins, including CSDC2, have been linked to various diseases, including cancer and inflammatory diseases. The ability of these proteins to regulate the expression of disease-associated genes makes them potential targets for therapeutic interventions .

Recombinant Production

With the advent of recombinant DNA technology, the expression and production of recombinant proteins, including CSDC2, have become feasible and cost-effective. Recombinant CSDC2 can be produced in various host organisms, providing a valuable tool for research and potential therapeutic applications .

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