CSE Antibody

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Cat. No.
BT1214967
Synonyms
CSE antibody; At1g52760 antibody; F14G24.3Caffeoylshikimate esterase antibody; EC 3.1.1.- antibody; Lysophospholipase 2 antibody; LysoPL2 antibody
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Description

Applications in Research

CSE antibodies are widely used in:

ApplicationDetails
Western Blot (WB)Validated in lysates from HeLa, HepG2, PC-3, and NIH/3T3 cells .
Immunohistochemistry (IHC)Detects CSE in human lung/liver cancer tissues and murine hepatocytes/kidney tubuli .
Immunofluorescence (IF)Localizes CSE in HepG2 cells .
ELISAQuantifies CSE in serum/urine for clinical studies (e.g., neurocysticercosis) .

Role in Cancer Biology

  • Breast Cancer: CSE is upregulated in triple-negative breast cancer (TNBC) and ER+ tumors. Antibody-based studies show CSE promotes proliferation, migration, and tamoxifen resistance via H₂S-mediated pathways .

    • Example: IHC revealed 71% sensitivity for CSE in breast cancer tissues vs. adjacent non-tumor samples .

  • Colorectal Cancer: CSE deficiency in bone marrow-derived cells accelerates colitis-associated carcinogenesis by altering IL-10/IL-6 balance .

Therapeutic Targeting

  • Inhibitor Development: The CSE inhibitor I194496 reduces TNBC growth by suppressing PI3K/Akt and Ras/ERK pathways (IC₅₀ = 0.79 mM for CSE) .

  • Biomarker Potential: Anti-CSE antibodies in serum correlate with neurocysticercosis treatment response (66.6% sensitivity pre-treatment) .

Diagnostic Utility

  • Neurocysticercosis: Anti-CSE antibodies in serum decline post-albendazole therapy, showing utility in monitoring treatment efficacy :

AntigenPre-Treatment Positivity3–6 Months Post-Treatment12 Months Post-Treatment
CSE42.4%15.1%15.1%
ES66.6%6%0%

Autoimmunity

  • Anti-CSE antibodies are linked to celiac disease (71% sensitivity, 99% specificity) and dissipate post-gluten-free diet .

Future Directions

  • Therapeutic Strategies: CSE inhibitors like I194496 may reverse tamoxifen resistance in ER+ breast cancer .

  • Biomarker Validation: Large-scale studies are needed to confirm CSE’s role in predicting cancer metastasis or drug resistance .

Product Specs

Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (Made-to-order)
Synonyms
CSE antibody; At1g52760 antibody; F14G24.3Caffeoylshikimate esterase antibody; EC 3.1.1.- antibody; Lysophospholipase 2 antibody; LysoPL2 antibody
Target Names
CSE
Uniprot No.
Q9C942

Target Background

Function
This antibody targets caffeoyl shikimate esterase (CSE), an enzyme crucial in lignin biosynthesis. CSE hydrolyzes caffeoylshikimate to caffeate and shikimate. In conjunction with 4-coumarate:CoA ligase (4CL), it provides an alternative pathway for caffeoyl-CoA formation, bypassing the second reaction of shikimate O-hydroxycinnamoyltransferase (HST). While exhibiting lower activity, CSE also accepts 4-coumaroylshikimate as a substrate. In vitro studies (PubMed:20345607 and PubMed:22915575) suggest additional enzymatic activities, including monoacylglycerol O-acyltransferase, monoacylglycerol lipase, and lysophospholipase. Furthermore, association with ACBP2 may enhance lysophosphatidylcholine degradation and mitigate cadmium-induced oxidative stress by detoxifying peroxidized membranes. However, in vivo validation of these additional activities is needed.
Gene References Into Functions
Caffeoyl shikimate esterase (CSE) is a key enzyme in the lignin biosynthetic pathway. In collaboration with 4-coumarate:CoA ligase (4CL), it circumvents the second HCT reaction. [PMID: 23950498](https://www.ncbi.nlm.nih.gov/pubmed/23950498)
Database Links

KEGG: ath:AT1G52760

STRING: 3702.AT1G52760.1

UniGene: At.24466

Protein Families
AB hydrolase superfamily, Monoacylglycerol lipase family
Subcellular Location
Cell membrane; Peripheral membrane protein. Note=Colocalizes with ACBP2.
Tissue Specificity
Expressed in vasculature of roots and leaves, stems, flowers and siliques.

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