CSN1 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
Preservative: 0.03% ProClin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (Made-to-order)
Synonyms
CSN1 antibody; COP11 antibody; FUS6 antibody; At3g61140 antibody; T20K12.40COP9 signalosome complex subunit 1 antibody; CSN complex subunit 1 antibody; Constitutive photomorphogenesis protein 11 antibody; Protein FUSCA 6 antibody
Target Names
CSN1
Uniprot No.
Target Background
Function
This antibody targets CSN1, a component of the COP9 signalosome complex (CSN). The CSN complex plays a crucial role in diverse cellular and developmental processes, including photomorphogenesis and responses to auxin and jasmonate. A key function of the CSN complex is the regulation of the ubiquitin (Ub) conjugation pathway. Specifically, it mediates the deneddylation of cullin subunits within SCF-type E3 ubiquitin ligase complexes, thereby modulating their activity. This regulation is essential for repressing photomorphogenesis in darkness by controlling the activity of COP1-containing Ub ligase complexes. Furthermore, CSN1 is involved in the degradation of IAA6 through the regulation of the SCF-TIR Ub ligase complex. Within the CSN complex, CSN1 is central to its overall assembly.
Gene References Into Functions
References:
- The interaction of TSA1 with CSN1 and its involvement in Arabidopsis seedling development under dark conditions has been documented. PMID: 22133685
Database Links
Protein Families
CSN1 family
Subcellular Location
Cytoplasm. Nucleus.
Tissue Specificity
Expressed in leaves, flowers, immature siliques, and light-grown roots.
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
