60 kDa cell wall Antibody

Key findings from experimental murine models:

Table 1: Strain-Specific Immune Responses to gp60

• Antibodies against gp60 demonstrate dual functionality:

  1. Diagnostic value via ELISA detection in patient sera

  2. Immunomodulatory effects that downregulate both Th1 and Th17 responses

Functional Implications

• Virulence association: Strains lacking gp60 show reduced pathogenicity in animal models .

• Therapeutic potential: Vaccination trials using gp60 induce protective immunity in 40–60% of test subjects .

• Diagnostic utility:

  • Recognized by 78–92% of human sporotrichosis cases

  • Cross-reacts with feline antibodies, enabling veterinary applications

Technical Detection Methods

Comparative Analysis with Other 60 kDa Antibodies

While sharing molecular weight similarities, the 60 kDa cell wall antibody differs fundamentally from:

• Heat shock protein 60 (HSP60) antibodies: Target intracellular stress proteins in autoimmune diseases

• Ro/SSA antibodies: Recognize nuclear ribonucleoproteins in lupus/Sjögren syndrome