CXCR2 Antibody

• The CXCR2 rs1126579 TT genotype was associated with a significantly increased likelihood of spontaneous HCV clearance. PMID: 29948377
• CXCR2 protein expression was upregulated in both the epileptic foci of temporal lobe epilepsy patients and in the pilocarpine mouse model. Administration of the CXCR2-selective antagonist SB225002 during the latency window preceding spontaneous recurrent seizures (SRSs) onset suppressed SRSs activity during the chronic period of epilepsy. PMID: 28705496
• Results indicated that the CXCR2 +1208 CT genotype is less frequent in advanced stages of prostate cancer, suggesting that this chemokine receptor plays a role in the pathogenesis of this disease. PMID: 28668699
• CXCR2 expression promotes both local and distant metastasis of colorectal cancer (CRC) and is associated with unfavorable prognosis for CRC patients. Furthermore, CXCR2 can stratify high-risk patients, particularly in those with normally early stage low-risk CRC. PMID: 28415702
• PADI4 contributes to gastric tumorigenesis by upregulating CXCR2, KRT14, and TNF-alpha expression. PMID: 27556695
• KHSV miR-K3 activates the GRK2/CXCR2/AKT axis, inducing KSHV-induced angiogenesis and promoting KSHV latency. PMID: 27058419
• CXCR2 mRNA and protein expression levels were significantly decreased in preeclamptic placentas compared to normal controls. Silencing CXCR2 significantly inhibited the invasive abilities of two trophoblast cell lines, while CXCR2 overexpression promoted trophoblast cell invasion. PMID: 27324095
• CXCR2 promotes breast cancer metastasis and chemoresistance by suppressing AKT1 and activating COX2. PMID: 28964785
• CXCR2 is required for the recruitment of tumor-associated neutrophils (TANs), which in turn suppress antitumor T-cell responses. CXCR2 ligands, particularly CXCL5, are elevated in both human and mouse pancreatic ductal adenocarcinoma (PDA). PMID: 27737879
• This study demonstrates that neutrophil expression levels of CVCR2 are decreased in septic patients. PMID: 27016001
• CXCR4 and CXCR2 were highly expressed in a highly invasive gastric cancer cell model and in gastric cancer tissues. Crosstalk between CXCR4 and CXCR2 contributed to epithelial-mesenchymal transition (EMT), migration, and invasion of gastric cancer. PMID: 28481874
• A unique viral protein, vCXCL1, targets three chemokine receptors: CXCR1 and CXCR2 expressed on neutrophils and CXCR1 and CX3CR1 expressed on Natural killer cells. PMID: 27160907
• The expressions of CXCL1 in cancer cells and CXCR2 in stromal cells are useful prognostic factors for gastric cancer patients. PMID: 28575019
• CXCR2 preferentially supports the maintenance of human pluripotent stem cell characteristics as well as facilitates ectodermal differentiation after commitment to differentiation. This mechanism might be associated with mTOR, beta-catenin, and hTERT activities. PMID: 27188501
• Results showed that CXCR2 expression was correlated with high grade (P = 0.024), advanced stage (P = 0.029), and metastasis (P = 0.018). The log-rank test revealed that high CXCR2 and CXCR3 expressions are related to poorer overall survival (P < 0.001; P < 0.001). PMID: 27273823
• These data demonstrate that the CXCR2 network and CXCL4 play a role in the maintenance of normal hematopoietic stem cell/hematopoietic progenitor cell (HSC/HPC) cell fates, including survival and self-renewal. PMID: 27222476
• CXCR1 and CXCR2 regulate hepatocyte exosome release. While the mechanism utilized by CXCR1 remains elusive, CXCR2 appears to modulate neutral sphingomyelinase (Nsm) activity and resultant production of ceramide to control exosome release. CXCR1 is required for packaging of enzymes into exosomes that mediate their hepatocyte proliferative effect. PMID: 27551720
• TNF-alpha augments CXCR2 and CXCR3 to promote the progression of renal cell carcinoma, leading to a poor prognosis. PMID: 27297979
• Data indicate that the crystal structure of PDZ-RhoGEF PDZ domain in complex with the CXC chemokine receptor 2 (CXCR2) C-terminal PDZ binding motif. PMID: 28179147
• Treatment with 1,25D3 increased poly(I:C)-induced IL-8 mRNA and protein expression after 2 to 6 hours. However, when cells were pretreated with 1,25D3 for 24 hours, 1,25D3 decreased cytokine expression. PMID: 27196318
• Novel pathways associated with GPI-AP- granulocytes were identified using RNA-seq, and higher CXCR2 expression was validated in GPI-AP- than GPI-AP+ granulocytes. PMID: 28151558
• Results identify the CXCL2/MIF-CXCR2 axis as an important mediator in myeloid-derived suppressor cell (MDSC) recruitment and as predictors in bladder cancer. PMID: 27721403
• This study demonstrates that CXCR2 signaling in the myeloid compartment is tumor-promoting and required for pancreatic cancer metastasis. PMID: 27265504
• The usefulness of CXCR-2 as a potential tumor marker of esophageal cancer was investigated. PMID: 27906878
• This study shows that downregulation of CD182 after stimulation with IL-8 is more pronounced in adults than in neonates, whereas formyl-methionyl-leucyl-phenylalanine (fMLP) induces changes in receptor expression that are of the same magnitude in neutrophils from neonates as from adults. PMID: 27606963
• Findings present that miR-940 acts as a pivotal adaptor of CXCR2 and its transcription downregulated CXCR2 expression to decrease hepatocellular carcinoma (HCC) invasion and migration in vitro. PMID: 27807540
• Our findings suggest that CXCL3 and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells, and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis. PMID: 26837773
• Data suggest that neutrophil-activating peptide 2 (NAP-2) secreted by natural killer (NK) cells can bind to CXC Chemokine Receptor 2 (CXCR2) on mesenchymal stem cells (MSCs) leading to stimulation of its recruitment. PMID: 27052313
• High CXCR2 expression is associated with pancreatic cancer. PMID: 26771140
• The results of this study show that the CXCR2 rs1126579 polymorphism is significantly associated with ischemic stroke, both individually and in combination with the genotype and/or alleles of other chemokine genes. PMID: 26648969
• These studies provide direct evidence linking the activation of IL8, DNA demethylation, and the induction of the osteoarthritis (OA) process with important therapeutic implications for patients with this debilitating disease. PMID: 26521741
• CXCR2 expression is enriched in human atherosclerotic coronary artery. PMID: 26287498
• The CXCR2-CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma. PMID: 26503598
• It was found that the mRNA level of NF-kappaB and IL-8 was higher in gastric ulcer patients, especially in patients with H.pylori-positive gastric ulcer. PMID: 26060478
• This study shows that CXCL5 expression is elevated in positive correlation to bladder cancer grade and promotes cell migration and invasion via binding to its receptor CXCR2. PMID: 26058729
• CXCR2 positivity combined with postoperative complications is associated with subsequent tumor recurrence in esophageal cancer. PMID: 26231560
• IL-10 rs1800896, CXCR2 rs1126579, and selected clinical features can be used as markers for septic shock development but not for decreased survival. PMID: 26038959
• Changes in promoter methylation patterns were investigated using methylation arrays and it was observed that the promoters of immunomodulatory factors, COX2 and PTGES, and migration-related factors, CXCR2 and CXCR4, were hypomethylated after 5-aza treatment. PMID: 25620445
• TLR3 stimulates the differentiation of mesenchymal stromal cells from human tonsils into follicular dendritic cell-like cells and induces chemokine secretion, possibly by recruiting C-X-C chemokine receptor 2-expressing immune cells. PMID: 25794662
• Data show that long non-coding RNA (lncRNA) MALAT1 silencing downregulated the expression of the microRNA miR-22-3p target gene CXCR2 and the AKT pathway. PMID: 26364720
• Data revealed a critical role of a PDZ-based CXCR2 macromolecular complex in endothelial progenitor cell (EPC) homing and angiogenesis. PMID: 25622052
• Results demonstrated that resistance to anti-proliferative effects of CXCR2 may also arise from feedback increases in macrophage inflammatory protein-2 (MIP-2) secretion. PMID: 25682075
• CXCR2 is a potential independent adverse prognostic biomarker for recurrence and survival of patients with non-metastatic clear cell renal cell carcinoma (ccRCC) after nephrectomy. PMID: 26188847
• Results showed that Helicobacter pylori (H. pylori) induced the activation of Jak1/Stat3 and IL-8 production, which was inhibited by a Jak/Stat3-specific inhibitor AG490 in AGS cells in a dose-dependent manner. PMID: 25837197
• Data indicate that the antibodies bound specifically to CXC chemokine receptor-2 (CXCR2)-expressing cells. PMID: 25484047
• Data indicate the antibodies recognized distinct epitopes of CXC chemokine receptor-2 (CXCR2). PMID: 25484064
• Our results reveal that circulating concentrations of IL-8 and IL-12 increase along with important vascular threatening traits such as fasting serum glucose and very low-density lipoprotein cholesterol (VLDL-c), respectively. PMID: 25456886
• miR141-CXCL1-CXCR2 signaling-induced regulatory T cell (Treg) recruitment regulates metastases and survival of non-small cell lung cancer. PMID: 25349304
• A 3' untranslated region (3'UTR) single nucleotide polymorphism (SNP) modulates CXCR2 expression, signaling, and susceptibility to lung cancer. PMID: 25480945
• Data demonstrate that CXCR2 regulates bone marrow blood vessel repair/regeneration and hematopoietic recovery, and clinically may be a therapeutic target for improving bone marrow transplantation. PMID: 25757087

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HGNC: 6027

OMIM: 146928

KEGG: hsa:3579

STRING: 9606.ENSP00000319635

UniGene: Hs.846