CB5-A Antibody

• Function: Blocks cleavage of complement component C5, inhibiting downstream pro-inflammatory effects (C5a anaphylatoxin and MAC formation) .

• Species Specificity: Effective in mice only; no cross-reactivity with human C5 .

• Binding Affinity:

  $$K_D = 8.10 \times 10^{-9}\, \text{M},\quad k_{\text{off}} = 0.0013\, \text{s}^{-1}$$

• Applications: Validated in arthritis, renal injury, and neurodegenerative models .

C5/473: A Diagnostic CD5 Antibody

• Target: CD5 transmembrane glycoprotein (67 kDa) .

• Clinical Use:

  • Diagnoses mantle cell lymphoma and chronic lymphocytic leukemia.

  • Differentiates thymic carcinoma (-) from thymoma (+) .

Comparative Analysis of Anti-C5/C5a Antibodies

Research Gaps and Recommendations

1. Term Clarification: Verify if "CB5-A" refers to a proprietary or developmental antibody not yet published.

2. Alternative Targets: Explore antibodies targeting C5 (complement) or CD5 (lymphocyte marker), which share functional or structural similarities.

3. Experimental Validation: If CB5-A is a novel antibody, provide sequence data, epitope mapping, and in vitro neutralization assays to establish its profile.