CYB5R4 Antibody
Description
Introduction to CYB5R4 Antibody
CYB5R4 antibodies are polyclonal or monoclonal reagents that specifically bind to the CYB5R4 protein (UniProt: Q7L1T6), a flavoenzyme involved in redox homeostasis. These antibodies enable researchers to investigate CYB5R4’s role in protecting pancreatic β-cells from reactive oxygen species (ROS) , regulating lipid metabolism , and influencing iron homeostasis .
Biological Significance of CYB5R4
CYB5R4 is implicated in:
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Oxidative Stress Protection: Reduces ROS accumulation in pancreatic β-cells, preserving insulin secretion under metabolic stress .
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Lipid Regulation: Facilitates fatty acid desaturation and cholesterol biosynthesis .
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Disease Pathways: Linked to diabetic retinopathy (via mitochondrial oxidative stress) , cancer progression (e.g., suppressed tumor migration in nasopharyngeal cancer) , and diabetes .
Western Blotting
Immunohistochemistry
ELISA
Diabetes and Metabolic Disorders
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CYB5R4 deficiency correlates with β-cell dysfunction and insulin resistance .
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NCB5OR (a related gene) mutations are associated with type 2 diabetes and lipoatrophy .
Cancer Research
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Nasopharyngeal Cancer: CYB5R2 (a paralog) suppresses angiogenesis and tumor migration .
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Colorectal Cancer: Frameshift mutations in CYB5R2 result in truncated proteins linked to tumorigenesis .
Neurological and Vascular Roles
Comparative Analysis of CYB5R4 Antibodies
Below is a comparison of commercially available CYB5R4 antibodies:
Product Specs
Target Background
- Cytosolic localization of NADH cytochrome b oxidoreductase PMID: 26878259
- Data provide the first evidence for natural mutations in the NCB5OR gene, resulting in decreased protein levels and potentially contributing to human pathology. PMID: 23523930
- Mutation in cytochrome b5 reductase is associated with developmental delay and severe neurological problems. PMID: 22627575
- Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain. PMID: 20630863
- NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum PMID: 15131110
- Variation in the coding region is not a major contributor to the pathogenesis of nonautoimmune diabetes. PMID: 15504981
